Nitrocamptothecin
Nitrocamptothecin (also known as 9-nitrocamptothecin or 9-NC) is a derivative of the naturally occurring alkaloid camptothecin. It is a potent topoisomerase I inhibitor, which interferes with the DNA replication process, making it a useful agent in cancer treatment.
History[edit | edit source]
Nitrocamptothecin was first synthesized in the late 20th century as part of a broader effort to develop more effective chemotherapeutic agents. It was derived from camptothecin, a compound originally isolated from the Chinese Happy Tree (Camptotheca acuminata).
Mechanism of Action[edit | edit source]
As a topoisomerase I inhibitor, nitrocamptothecin works by stabilizing the complex formed between topoisomerase I and DNA, preventing the re-ligation of DNA strands and leading to DNA damage. This damage triggers apoptosis, or programmed cell death, in cancer cells.
Clinical Use[edit | edit source]
Nitrocamptothecin has been studied in a variety of cancer types, including colorectal cancer, pancreatic cancer, and ovarian cancer. It has shown promise in early-phase clinical trials, but further research is needed to fully understand its potential benefits and risks.
Side Effects[edit | edit source]
Like many chemotherapeutic agents, nitrocamptothecin can cause a range of side effects. These may include nausea, vomiting, diarrhea, and myelosuppression, a condition characterized by decreased production of blood cells in the bone marrow.
Future Research[edit | edit source]
Ongoing research is exploring the potential of nitrocamptothecin in combination with other drugs, as well as its use in treating other types of cancer.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
