Pathognomonic

From WikiMD's Wellness Encyclopedia

"Pathognomonic" is a term predominantly employed in the realm of medicine, signifying a sign or symptom that is so characteristically associated with a particular disease or condition that its presence confirms the diagnosis beyond any reasonable doubt. The term "pathognomonic" amplifies the diagnostic certainty of a condition compared to a regular diagnostic sign or symptom. Recognizing pathognomonic signs is vital in clinical practice as they allow for prompt and accurate diagnosis, ensuring timely and appropriate treatment.

Definition and Origin[edit | edit source]

  • Term: Pathognomonic (occasionally spelled "pathognomic")
  • Definition: A sign or symptom that is so distinctive to a specific disease or condition that its mere presence confirms the diagnosis unequivocally.
  • Etymology: Derived from the Greek words "pathos" (disease) and "gnomon" (indicator).

Clinical Importance[edit | edit source]

Identifying a pathognomonic sign in a patient can greatly aid in the diagnostic process, allowing for rapid intervention and reducing the reliance on more costly or invasive diagnostic measures. However, it's crucial to understand that many diseases don't possess pathognomonic signs, necessitating comprehensive clinical evaluations.

Examples[edit | edit source]

Disease Sign
Cytomegalovirus infection Owl's eye appearance of inclusion bodies
Hodgkin's lymphoma Reed-Sternberg cells (giant mono- and multinucleated cells) upon microscopy
Lyme disease Erythema chronicum migrans
Inclusion body myositis Filamentous material seen in inclusion bodies under electron microscopy
Hypocalcemia Trousseau sign and Chvostek sign
Tetanus or Strychnine poisoning Risus sardonicus
Measles Koplik's spots
Wilson's disease Kayser–Fleischer ring
Diphtheria Pseudomembrane on tonsils, pharynx, and nasal cavity
Chronic hemorrhagic pancreatitis Grey-Turner's sign (ecchymosis in flank area)
Cholera Rice-watery stool
Enteric fever Rose spots on the abdomen
Meningitis Kernig's sign and Brudzinski's sign
Angina pectoris Levine's sign (hand clutching of chest)
Patent ductus arteriosus Machine-like murmur
Parkinson's disease Pill-rolling tremors
Whipple's disease Oculo-masticatory myorhythmia
Acute myeloid leukemia Auer rod
Multiple sclerosis Bilateral internuclear ophthalmoplegia
Pericarditis Pericardial friction rub
Rheumatic fever Aschoff bodies
Rabies Hydrophobia and negri bodies
Gout Tophi
MASC ETV6-NTRK3
Acute tubular necrosis Muddy brown casts
Granulosa cell tumour Call-Exner bodies
Malakoplakia Michaelis–Gutmann bodies
Narcolepsy (with cataplexy) Cataplexy
Endodermal sinus tumor Schiller–Duval body
Sickle cell disease Vaso-occlusive crises

See also[edit | edit source]

Pathognomonic Resources
Wikipedia
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Contributors: Prab R. Tumpati, MD