TRPC3

TRPC3 or Transient Receptor Potential Cation Channel Subfamily C Member 3 is a protein that in humans is encoded by the TRPC3 gene. It is a member of the transient receptor potential channel family and is a non-selective cation channel that is activated in response to intracellular calcium depletion.

Function

TRPC3 is a non-selective cation channel that is activated in response to intracellular calcium depletion. It is thought to be involved in the regulation of calcium homeostasis, and has been implicated in a variety of cellular processes, including cell proliferation, neuronal excitability, and synaptic plasticity.

Structure

The TRPC3 protein is composed of six transmembrane domains, with a pore region located between the fifth and sixth domains. It also contains a number of ankyrin repeats in its N-terminal region, which are thought to be involved in protein-protein interactions.

Clinical significance

Mutations in the TRPC3 gene have been associated with a number of diseases, including spinocerebellar ataxia and familial episodic pain syndrome. In addition, overexpression of TRPC3 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

Research

Research into the function and regulation of TRPC3 is ongoing, with a particular focus on its role in calcium homeostasis and its potential as a therapeutic target in a variety of diseases.

See also

• Transient receptor potential channel
• Calcium homeostasis
• Spinocerebellar ataxia
• Familial episodic pain syndrome

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External links

• Comprehensive information from the National Institute of health.
  

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