TRPC3

TRPC3 or Transient Receptor Potential Cation Channel Subfamily C Member 3 is a protein that in humans is encoded by the TRPC3 gene. It is a member of the transient receptor potential channel family and is a non-selective cation channel that is activated in response to intracellular calcium depletion.

Function

TRPC3 is a non-selective cation channel that is activated in response to intracellular calcium depletion. It is thought to be involved in the regulation of calcium homeostasis, and has been implicated in a variety of cellular processes, including cell proliferation, neuronal excitability, and synaptic plasticity.

Structure

The TRPC3 protein is composed of six transmembrane domains, with a pore region located between the fifth and sixth domains. It also contains a number of ankyrin repeats in its N-terminal region, which are thought to be involved in protein-protein interactions.

Clinical significance

Mutations in the TRPC3 gene have been associated with a number of diseases, including spinocerebellar ataxia and familial episodic pain syndrome. In addition, overexpression of TRPC3 has been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

Research

Research into the function and regulation of TRPC3 is ongoing, with a particular focus on its role in calcium homeostasis and its potential as a therapeutic target in a variety of diseases.

See also

• Transient receptor potential channel
• Calcium homeostasis
• Spinocerebellar ataxia
• Familial episodic pain syndrome

edit 

WikiMD neurology

External links

• Comprehensive information from the National Institute of health.
  

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian