Testosterone formate
Testosterone formate is an androgen and anabolic steroid and a testosterone ester. It is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.
Chemistry[edit]
Testosterone formate, or testosterone formic acid, is a synthetic estrane steroid and a derivative of testosterone. It is an androgen ester; specifically, it is the C17β formate (formic acid) ester of testosterone.
Pharmacology[edit]
As an ester of testosterone, testosterone formate is considered to be a prodrug of testosterone. When administered via intramuscular injection, it is stored in the fatty tissue and slowly released over time, resulting in a long-lasting effect. The formate ester prolongs the release of testosterone into the system, making it effective for use in androgen replacement therapy.
Medical uses[edit]
Testosterone formate is used primarily in the treatment of male hypogonadism, a condition in which the body does not produce enough testosterone. It can also be used in hormone therapy for transgender men. It is administered via intramuscular injection.
Side effects[edit]
Potential side effects of testosterone formate include gynecomastia, increased sexual desire, and various psychological changes. As with all testosterone products, testosterone formate carries a risk of serious side effects such as cardiovascular disease and prostate cancer.
Research[edit]
Testosterone formate is currently under research for use as a male contraceptive. In combination with a progestin, it has been found to effectively suppress spermatogenesis, the process of sperm cell development.
See also[edit]
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