Xarelto

Xarelto (rivaroxaban) is an anticoagulant medication used to prevent and treat blood clots. It is part of a class of drugs known as direct oral anticoagulants (DOACs), which also includes apixaban (Eliquis), dabigatran (Pradaxa), and edoxaban (Savaysa). Xarelto is manufactured by Bayer and was first approved by the Food and Drug Administration (FDA) in 2011.

Uses

Xarelto is used to prevent deep vein thrombosis (DVT), which can lead to pulmonary embolism (PE), in people who have had hip or knee replacement surgery. It is also used to reduce the risk of stroke and systemic embolism in people with nonvalvular atrial fibrillation.

Side Effects

Common side effects of Xarelto include bleeding, anemia, and bruising. Serious side effects can include spinal or epidural hematoma, which can cause long-term or permanent paralysis.

Mechanism of Action

Xarelto works by inhibiting factor Xa, an enzyme involved in the coagulation cascade. This prevents the formation of a blood clot.

Contraindications

Xarelto is contraindicated in people with active pathological bleeding or a hypersensitivity to rivaroxaban.

See Also

• Anticoagulant
• Deep vein thrombosis
• Pulmonary embolism
• Atrial fibrillation

Xarelto Resources
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