From WikiMD's Food, Medicine & Wellness Encyclopedia

1,2-Propanedithiol is a chemical compound with the molecular formula C3H8S2. It is a colorless liquid with a strong, unpleasant odor, similar to that of garlic. This compound is used in the synthesis of other chemicals, particularly in the production of pharmaceuticals and agrochemicals.

Structure and Properties[edit | edit source]

1,2-Propanedithiol consists of a three-carbon alkane chain with a sulfhydryl group (–SH) attached to each of the two end carbons. The presence of these sulfhydryl groups gives the compound its characteristic odor and also contributes to its reactivity.

The molecular weight of 1,2-propanedithiol is 124.22 g/mol. It has a boiling point of 153-154 °C and a melting point of -50 °C. It is soluble in water and most organic solvents.

Synthesis[edit | edit source]

1,2-Propanedithiol can be synthesized by the reaction of propylene oxide with hydrogen sulfide in the presence of a catalyst. The reaction proceeds via a nucleophilic substitution mechanism, with the hydrogen sulfide acting as the nucleophile.

Uses[edit | edit source]

1,2-Propanedithiol is primarily used as a building block in the synthesis of other chemicals. It is a key intermediate in the production of certain pharmaceuticals and agrochemicals. It can also be used as a reducing agent in various chemical reactions.

Safety[edit | edit source]

1,2-Propanedithiol is a strong irritant and can cause burns to the skin and eyes. It is also harmful if swallowed or inhaled. Proper safety measures should be taken when handling this compound.

See Also[edit | edit source]

References[edit | edit source]


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Contributors: Prab R. Tumpati, MD