Adma

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Adma
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Adma is a medical condition characterized by specific physiological and biochemical abnormalities. It is primarily studied within the field of cardiology due to its impact on cardiovascular health.

Pathophysiology[edit | edit source]

Adma, or Asymmetric Dimethylarginine, is a naturally occurring chemical found in blood plasma. It is a derivative of the amino acid arginine and is produced as a result of protein modification processes. Adma is known to inhibit the production of nitric oxide (NO), a critical molecule involved in vascular homeostasis. NO is synthesized by endothelial cells and plays a vital role in maintaining vascular tone, blood pressure, and endothelial function.

The accumulation of Adma in the bloodstream can lead to endothelial dysfunction, which is a precursor to atherosclerosis and other cardiovascular diseases. Elevated levels of Adma are associated with increased risk of hypertension, coronary artery disease, and chronic kidney disease.

Causes[edit | edit source]

The primary cause of elevated Adma levels is impaired degradation by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Factors that can lead to increased Adma levels include:

Clinical Significance[edit | edit source]

Adma is considered a biomarker for cardiovascular risk. Elevated levels of Adma have been linked to:

Diagnosis[edit | edit source]

The diagnosis of elevated Adma levels is typically made through blood tests that measure its concentration in plasma. These tests are often used in conjunction with other assessments of cardiovascular risk.

Treatment[edit | edit source]

There is currently no specific treatment for reducing Adma levels directly. However, managing underlying conditions and risk factors can help mitigate its effects. Treatment strategies may include:

Research[edit | edit source]

Ongoing research is focused on understanding the role of Adma in cardiovascular disease and exploring potential therapeutic interventions. Studies are investigating the impact of various drugs on Adma levels and their potential to improve endothelial function.

See also[edit | edit source]

External links[edit | edit source]

  • [Link to relevant medical resources]


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Contributors: Prab R. Tumpati, MD