Dimethandrolone buciclate
Dimethandrolone buciclate (also known as 7α,11β-dimethyl-19-nortestosterone 17β-buciclate or DMAU) is a synthetic and injectable anabolic–androgenic steroid (AAS) and a derivative of nandrolone which is currently under development for potential use as a long-acting male contraceptive and treatment for hypogonadism.
Pharmacology[edit | edit source]
Dimethandrolone buciclate is a prodrug of dimethandrolone (DMA), which is a potent agonist of the androgen receptor and the progesterone receptor with weaker activity at the estrogen receptor. The drug has a very long duration of action when given by intramuscular injection, with a single dose having been found to suppress gonadotropin levels for up to 12 weeks in clinical studies.
Clinical studies[edit | edit source]
Clinical studies of dimethandrolone buciclate have been conducted in men. The drug has been found to produce dose-dependent suppression of spermatogenesis and to be well-tolerated. It is currently in phase II clinical trials for use as a male contraceptive.
Potential applications[edit | edit source]
In addition to potential use as a male contraceptive, dimethandrolone buciclate may also be useful for the treatment of hypogonadism, muscle wasting associated with cachexia, and osteoporosis, among other indications.
See also[edit | edit source]
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Dimethandrolone buciclate
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