LY-367,385
| LY-367,385_structure.png | |
LY-367,385 is a chemical compound that acts as a selective antagonist for the metabotropic glutamate receptor 1 (mGluR1). It is primarily used in scientific research to study the role of mGluR1 in various physiological and pathological processes.
Pharmacology[edit | edit source]
LY-367,385 is known for its high selectivity towards the mGluR1 receptor, which is a subtype of the metabotropic glutamate receptor family. These receptors are G-protein coupled receptors that play a crucial role in modulating synaptic transmission and neuronal excitability in the central nervous system.
Mechanism of Action[edit | edit source]
As an antagonist, LY-367,385 binds to the mGluR1 receptor and inhibits its activation by endogenous ligands such as glutamate. This inhibition can help elucidate the physiological functions of mGluR1, as well as its involvement in various neurological disorders.
Research Applications[edit | edit source]
LY-367,385 is widely used in neuroscience research to:
- Investigate the role of mGluR1 in synaptic plasticity, learning, and memory.
- Study the involvement of mGluR1 in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
- Explore the potential therapeutic effects of mGluR1 antagonists in treating conditions like chronic pain, anxiety, and depression.
Chemical Properties[edit | edit source]
LY-367,385 is a cyclopropyl derivative of glycine, characterized by its unique structure that confers selectivity for the mGluR1 receptor. Its chemical formula is C₇H₉NO₄, and it has a molecular weight of 171.15 g/mol.
Safety and Handling[edit | edit source]
As with many research chemicals, LY-367,385 should be handled with care. Appropriate safety measures, including the use of personal protective equipment, should be employed when handling this compound in a laboratory setting.
Also see[edit | edit source]
- Metabotropic glutamate receptor
- Glutamate receptor
- Neurotransmitter receptor
- G-protein coupled receptor
Template:Receptor pharmacology
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Contributors: Prab R. Tumpati, MD
