LY-382884
LY-382884 is a chemical compound that acts as a selective antagonist of the glutamate receptor subtype known as the AMPA receptor. It is primarily used in scientific research to study the role of AMPA receptors in the central nervous system and their involvement in various neurological processes and disorders.
Chemical Structure and Properties[edit | edit source]
LY-382884 is a synthetic compound with the chemical formula C₁₆H₁₅NO₄. It is characterized by its ability to selectively inhibit the activity of AMPA receptors, which are a type of ionotropic glutamate receptor responsible for fast synaptic transmission in the brain.
Pharmacological Action[edit | edit source]
As an AMPA receptor antagonist, LY-382884 binds to the receptor and prevents the action of the neurotransmitter glutamate, thereby inhibiting excitatory synaptic transmission. This property makes it a valuable tool in neuroscience research for investigating the physiological and pathological roles of AMPA receptors.
Research Applications[edit | edit source]
LY-382884 is used extensively in preclinical studies to explore the function of AMPA receptors in various contexts, including:
- Neuroprotection: By blocking excitotoxicity mediated by excessive glutamate activity, LY-382884 is studied for its potential neuroprotective effects in conditions such as stroke and traumatic brain injury.
- Epilepsy: The compound is used to investigate the role of AMPA receptors in seizure activity and to evaluate potential therapeutic strategies for epilepsy.
- Cognitive Function: Research involving LY-382884 helps elucidate the contribution of AMPA receptors to learning and memory processes, as well as their potential involvement in cognitive disorders such as Alzheimer's disease.
Safety and Toxicology[edit | edit source]
While LY-382884 is a valuable research tool, its use is primarily restricted to laboratory settings. The safety profile of LY-382884 in humans is not well-established, and it is not approved for clinical use.
Also see[edit | edit source]
Template:Receptor pharmacology
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