Large cell medulloblastoma
A medulloblastoma composed of large cells with prominent nucleoli and a larger amount of cytoplasm in contrast with the cells of the classic medulloblastoma.
Histology[edit | edit source]
Medulloblastomas can be of the following types:
- Classic medulloblastoma
- Desmoplastic/nodular medulloblastoma,
- Medulloblastoma with extensive nodularity, and
- Large-cell/anaplastic medulloblastoma.
Features[edit | edit source]
- The “Large cell” medulloblastomas have focal or diffuse, large, round neoplastic cells with prominent nucleoli.
- “Anaplastic” MBs (A MBs) have nuclei that were also large but markedly atypical with coarse chromatin and irregular shapes.
Prognostic significance[edit | edit source]
- According to a study, patients with large cell medulloblastoma had higher relapse rates and worse survival than those with classic medulloblastoma or anaplastic medulloblastoma.
- Patients with either large cell or anaplastic medulloblastoma have the worst prognosis[1].
Treatment implications[edit | edit source]
Given the worse prognosis, which carries a high risk for recurrence, large cell medulloblastoma patients should be treated with the more aggressive treatment strategies.
Also see[edit | edit source]
External links[edit | edit source]
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