Meteneprost

Meteneprost

Meteneprost is a synthetic prostaglandin analog used primarily in the field of obstetrics and gynecology. It is known for its ability to induce labor and manage postpartum hemorrhage. This article provides a comprehensive overview of meteneprost, including its pharmacology, clinical applications, and safety profile.

Pharmacology

Meteneprost is a prostaglandin E1 analog. Prostaglandins are lipid compounds that have diverse hormone-like effects in animals. Meteneprost mimics the action of natural prostaglandins, which are involved in the regulation of the female reproductive system, among other physiological functions.

Mechanism of Action

Meteneprost works by binding to prostaglandin receptors in the uterus, leading to increased uterine contractions. This action is beneficial in inducing labor or controlling bleeding after childbirth. The drug's ability to stimulate uterine contractions makes it effective in managing certain obstetric conditions.

Pharmacokinetics

Meteneprost is administered via various routes, including oral, vaginal, and intramuscular. The choice of administration depends on the clinical scenario. Once administered, it is rapidly absorbed and metabolized in the body. The onset of action and duration can vary based on the route of administration.

Clinical Applications

Meteneprost is used in several clinical settings:

Induction of Labor

Meteneprost is used to induce labor in pregnant women who require assistance in starting the birthing process. It is particularly useful in cases where the cervix is not yet favorable for delivery.

Management of Postpartum Hemorrhage

Postpartum hemorrhage is a significant cause of maternal morbidity and mortality. Meteneprost helps in controlling excessive bleeding by promoting uterine contractions, which aid in the expulsion of retained placental tissue and reduce uterine atony.

Termination of Pregnancy

In some cases, meteneprost is used in combination with other medications to terminate a pregnancy. It is effective in inducing uterine contractions to expel the contents of the uterus.

Safety and Side Effects

While meteneprost is generally safe when used appropriately, it can cause side effects. Common side effects include nausea, vomiting, diarrhea, and abdominal pain. Serious side effects are rare but can include uterine rupture, especially if used improperly.

Contraindications

Meteneprost should not be used in women with a history of hypersensitivity to prostaglandins or in those with certain medical conditions that contraindicate the induction of labor, such as placenta previa or vasa previa.

Also see

• Prostaglandin
• Induction of labor
• Postpartum hemorrhage
• Termination of pregnancy