Netarsudil

What is Netarsudil?[edit | edit source]

Netarsudil (RHOPRESSA) (netarsudil ophthalmic solution) 0.02% is a Rho kinase inhibitor used for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

This medicine is used for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.

Netarsudil - an amino-isoquinoline amide and inhibitor of rho kinase (rock) and norepinephrine transporter (net), with potential intraocular pressure (iop)-lowering activity.
Upon ocular administration, netarsudil inhibits rock and the rho pathway, increases aqueous humor (ah) outflow via the trabecular pathway, and lowers iop.
In addition, netarsudil may lower iop by decreasing episcleral venous pressure and decreasing the production of aqueous humor through inhibition of net.

Recommended Dosageː The recommended dosage is one drop in the affected eye(s) once daily in the evening.

Administration

Take RHOPRESSA exactly as your doctor tells you to take it.
Take RHOPRESSA one drop in the affected eye(s) once daily in the evening.
If one dose is missed, treatment should continue with the next dose in the evening.
Twice a day dosing is not well tolerated and is not recommended.
If RHOPRESSA is to be used concomitantly with other topical ophthalmic drug products to lower IOP, administer each drug product at least 5 minutes apart.

This medicine is available in fallowing doasage form:

This medicine is available in fallowing brand namesː

The most common side effects of this medicine include:

Contact lenses should be removed prior to instillation of RHOPRESSA and may be reinserted 15 minutes following its administration.
Advise patients that if more than one topical ophthalmic drug is being used, the drugs should be administered at least 5 minutes between applications.
Instruct patients to avoid allowing the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution.

In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

Overdose related information is also available online at poisonhelp.org/help.
In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.

Safety and effectiveness in pediatric patients below the age of 18 years have not been established.

Active ingredient:

Inactive ingredients:

Store at 2°C to 8°C (36°F to 46°F) until opened. After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks.
If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle.
During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.

Netarsudil Resources
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