Vincristine
(Redirected from Onco TCS)
Vincristine (vin-KRIS-teen)The active ingredient in a drug used to treat acute leukemia.
- It is sometimes used with other drugs to treat Hodgkin lymphoma, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor.
- It is also being studied in the treatment of other types of cancer. Vincristine blocks cell growth by stopping cell division.
- It is a type of vinca alkaloid and a type of antimitotic agent.
Indications[edit | edit source]
Vincristine sulfate injection is indicated in acute leukemia. Vincristine sulfate injection has also been shown to be useful in combination with other oncolytic agents in Hodgkin's disease
How is it made?[edit | edit source]
- Vincristine Sulfate Injection, USP is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). Originally known as leurocristine, it has also been referred to as LCR and VCR.
Molecular formula[edit | edit source]
- The molecular formula for Vincristine Sulfate, USP is C46H56N4O10∙H2SO4.
- It has a molecular weight of 923.04.
- The structural formula is as follows:
- Vincristine Sulfate Injection, USP is a sterile, preservative–free, single-dose only solution available for intravenous use in 2 mL (1 mg and 2 mg) vials. Each mL contains 1 mg Vincristine Sulfate, USP, 100 mg mannitol and Water for Injection, USP. Q.S. Sulfuric acid or sodium hydroxide have been added for pH control.
Clinical pharmacology[edit | edit source]
The mechanisms of action of vincristine sulfate remain under investigation.
Mechanism of action[edit | edit source]
The mechanism of action of vincristine sulfate has been related to the inhibition of microtubule formation
Indications[edit | edit source]
Vincristine sulfate injection is indicated in acute leukemia. Vincristine sulfate injection has also been shown to be useful in combination with other oncolytic agents in Hodgkin's disease
How should not use this medicine?[edit | edit source]
Patients with the demyelinating form of Charcot–Marie–Tooth syndrome should not be given vincristine sulfate injection.
Precautions[edit | edit source]
General - Acute uric acid nephropathy, which may occur after the administration of oncolytic agents, has also been reported with vincristine sulfate.
Side effects[edit | edit source]
Prior to the use of this drug, patients and/or their parents/guardian should be advised of the possibility of untoward symptoms.
Overdosage[edit | edit source]
Side effects following the use of vincristine sulfate injection are dose related. ---Dosage==
- This preparation is for intravenous use only (see WARNINGS).
- Neurotoxicity appears to be dose related. Extreme care must be used in calculating and administering the dose of Vincristine
- Vincristine Sulfate Injection, USP, preservative free solution.
Warnings[edit | edit source]
- This preparation is for intravenous use only.
- It should be administered by individuals experienced in the administration of vincristine sulfate injection.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD