Diisopromine

Diisopromine

Diisopromine, also known by its alternative name disoprominum, is a synthetic spasmolytic compound. Most commonly found in its hydrochloride salt form, diisopromine is primarily used to counteract spastic conditions associated with the biliary tract and the sphincter of Oddi. Its discovery is credited to Janssen Pharmaceutica in the year 1955.

Chemical Properties

Diisopromine, in its prevalent form, is available as the hydrochloride salt. This ensures enhanced solubility and stability of the compound, making it suitable for pharmaceutical applications.

Mechanism of Action

While the exact mechanism of action of diisopromine remains a subject of research, its primary function is recognized as a spasmolytic agent. It works to neutralize spastic conditions, especially in the biliary tract and the sphincter of Oddi, thereby aiding in the alleviation of associated discomforts.

History

Diisopromine was first identified and synthesized in 1955 by the team at Janssen Pharmaceutica, a renowned pharmaceutical company. Since its discovery, it has been utilized in various therapeutic applications, particularly for addressing spastic conditions of specific digestive tract regions.

Medical Uses

The primary application of diisopromine lies in its ability to counteract spastic conditions. It offers relief from:

• Spastic conditions of the biliary tract: By relaxing the smooth muscles, diisopromine helps in easing the passage of bile through the biliary tract.
• Spastic conditions of the sphincter of Oddi: The sphincter of Oddi, a muscular valve controlling the flow of digestive juices to the duodenum, can at times experience spastic conditions. Diisopromine aids in relaxing this sphincter, ensuring smooth flow and preventing potential blockages.

Side Effects and Contraindications

As with all pharmaceuticals, diisopromine may have potential side effects. Patients are advised to consult with their healthcare professionals before starting any treatment.

See Also

• Spasmolytic agents
• Biliary tract
• Sphincter of Oddi dysfunction

References

• Diisopromine (NCBI, PubChem)

Diisopromine Resources
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