Left ventricular end diastolic pressure

A measure of pressure in the left ventricle of the heart at the end of diastole

Left Ventricular End Diastolic Pressure
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Left ventricular end diastolic pressure (LVEDP) is a critical measurement in cardiology that reflects the pressure in the left ventricle of the heart at the end of diastole, just before the ventricle contracts. It is an important parameter for assessing left ventricular function and hemodynamics.

Physiology

The left ventricle is one of the four chambers of the heart, responsible for pumping oxygenated blood into the systemic circulation via the aorta. During diastole, the heart muscle relaxes, allowing the ventricles to fill with blood. The pressure at the end of this filling phase is known as the left ventricular end diastolic pressure.

LVEDP is influenced by several factors, including:

• Preload: The initial stretching of the cardiac myocytes prior to contraction, which is related to the volume of blood returning to the heart.
• Compliance: The ability of the ventricular walls to stretch and accommodate blood.
• Afterload: The resistance the heart must overcome to eject blood.

Clinical Significance

LVEDP is a valuable indicator of cardiac function and is used to assess conditions such as:

• Heart failure: Elevated LVEDP can indicate worsening heart failure.
• Mitral valve disease: Changes in LVEDP can reflect the severity of mitral valve stenosis or regurgitation.
• Hypertrophic cardiomyopathy: LVEDP may be elevated due to impaired ventricular filling.

Measurement

LVEDP is typically measured using invasive techniques such as cardiac catheterization. During this procedure, a catheter is inserted into the heart via a blood vessel, and pressure measurements are taken directly from the left ventricle.

Non-invasive methods, such as echocardiography, can estimate LVEDP by assessing parameters like the E/A ratio and E/e' ratio, which reflect diastolic function.

Interpretation

Normal LVEDP values range from 4 to 12 mmHg. Values above this range may indicate:

• Left ventricular dysfunction
• Volume overload
• Increased systemic vascular resistance

Also see

• Cardiac cycle
• Diastolic dysfunction
• Echocardiography
• Heart failure
• Preload and afterload

Cardiovascular disease A-Z

Most common cardiac diseases

• Cardiac arrhythmia‎
• Cardiogenetic disorders‎
• Cardiomegaly‎
• Cardiomyopathy‎
• Cardiopulmonary resuscitation‎
• Chronic rheumatic heart diseases‎
• Congenital heart defects‎
• Heart neoplasia‎
• Ischemic heart diseases‎
• Pericardial disorders
• Syndromes affecting the heart‎
• Valvular heart disease‎

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

A

• Accelerated idioventricular rhythm
• Acute decompensated heart failure
• Arteriosclerotic heart disease
• Athletic heart syndrome
• Atrial flutter
• Atrioventricular fistula
• Cardiovascular disease in Australia
• Autoimmune heart disease

B

• Brown atrophy of the heart

C

• Ebb Cade
• Cardiac allograft vasculopathy
• Cardiac amyloidosis
• Cardiac asthma
• Cardiac tamponade
• Cardiogenic shock
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• Cardiorenal syndrome
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D

• Duke Treadmill Score
• Duroziez's disease

E

• Eisenmenger's syndrome
• Embryocardia
• Endocardial fibroelastosis
• Eosinophilic myocarditis

H

• Heart attack
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• Heart to Heart (1949 film)
• High-output heart failure
• Hyperdynamic precordium

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I

• Idiopathic giant-cell myocarditis
• Interventricular dyssynchrony
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• Isolated atrial amyloidosis

K

• Keshan disease

L

• Loeffler endocarditis

M

• Mydicar
• Myocardial bridge
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• Myocarditis

N

• Nonbacterial thrombotic endocarditis

O

• OLR1
• Ostial disease

P

• Papillary fibroelastoma
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• Postpericardiotomy syndrome
• Pulmonary vein stenosis

R

• Right axis deviation
• Roemheld syndrome

S

• Saturated fat and cardiovascular disease
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• Strain pattern
• Subacute bacterial endocarditis
• Sudden cardiac death of athletes

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T

• Traumatic cardiac arrest

V

• Ventricular aneurysm
• Vibroacoustic disease
• Viral cardiomyopathy

W

• Waon therapy