PLA2G4E (gene)

PLA2G4E (Phospholipase A2 Group IVE) is a gene that encodes the enzyme phospholipase A2. This enzyme is part of the larger family of phospholipases, which are responsible for the hydrolysis of phospholipids into fatty acids and other lipophilic substances.

Function

The PLA2G4E gene is responsible for the production of the enzyme phospholipase A2 group IVE. This enzyme plays a crucial role in the metabolism of phospholipids, which are a major component of all cell membranes. The enzyme catalyzes the hydrolysis of the sn-2 position of phospholipids, resulting in the release of arachidonic acid and lysophospholipids. These products are then further metabolized to produce eicosanoids, which are signaling molecules involved in various physiological and pathological processes.

Clinical significance

Mutations in the PLA2G4E gene have been associated with various diseases. For instance, a mutation in this gene has been linked to Parkinson's disease, a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra region of the brain.

See also

• Phospholipase A2
• Phospholipid
• Arachidonic acid
• Eicosanoid
• Parkinson's disease

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