STK17A

STK17A (also known as DRAK1) is a gene that encodes a serine/threonine kinase in humans. This gene is a member of the death-associated protein kinase (DAPK) family and is known to play a role in apoptosis, or programmed cell death.

Function

The protein encoded by the STK17A gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family. These kinases are associated with cellular apoptosis. The encoded protein is a strong inducer of apoptosis in response to various stimuli, suggesting a role in stress-induced cell death.

Clinical Significance

Alterations in the STK17A gene have been associated with various forms of cancer, including breast cancer and colorectal cancer. The gene's role in apoptosis suggests that it may function as a tumor suppressor, and its dysregulation could contribute to the development and progression of cancer.

Research

Research into the STK17A gene and its encoded protein is ongoing, with studies focusing on its role in apoptosis and potential as a target for cancer therapy.

See Also

• Serine/threonine-specific protein kinase
• Apoptosis
• Cancer