STK17A
STK17A (also known as DRAK1) is a gene that encodes a serine/threonine kinase in humans. This gene is a member of the death-associated protein kinase (DAPK) family and is known to play a role in apoptosis, or programmed cell death.
Function[edit | edit source]
The protein encoded by the STK17A gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family. These kinases are associated with cellular apoptosis. The encoded protein is a strong inducer of apoptosis in response to various stimuli, suggesting a role in stress-induced cell death.
Clinical Significance[edit | edit source]
Alterations in the STK17A gene have been associated with various forms of cancer, including breast cancer and colorectal cancer. The gene's role in apoptosis suggests that it may function as a tumor suppressor, and its dysregulation could contribute to the development and progression of cancer.
Research[edit | edit source]
Research into the STK17A gene and its encoded protein is ongoing, with studies focusing on its role in apoptosis and potential as a target for cancer therapy.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
