Sulfanegen
Sulfanegen is a drug that is used as an antidote for cyanide poisoning. It works by converting cyanide into thiocyanate, a less toxic compound that is excreted in urine. Sulfanegen is a prodrug of 3-mercaptopyruvate, which is the actual compound that detoxifies cyanide.
History[edit | edit source]
Sulfanegen was first synthesized in the early 21st century as part of a research program funded by the National Institutes of Health (NIH) to develop new antidotes for cyanide poisoning. The drug was developed by scientists at the University of Minnesota and the University of California, San Francisco.
Mechanism of action[edit | edit source]
Sulfanegen is a prodrug of 3-mercaptopyruvate. After administration, it is converted into 3-mercaptopyruvate by the enzyme 3-mercaptopyruvate sulfurtransferase. 3-Mercaptopyruvate then reacts with cyanide to form thiocyanate, which is less toxic and can be excreted in the urine.
Clinical use[edit | edit source]
Sulfanegen is used as an antidote for cyanide poisoning. It can be administered intravenously or orally. The drug is particularly useful in situations where cyanide exposure is chronic or where the source of exposure cannot be immediately removed.
Side effects[edit | edit source]
Like all drugs, sulfanegen can cause side effects. The most common side effects are nausea and vomiting. In rare cases, sulfanegen can cause allergic reactions.
Research[edit | edit source]
Research on sulfanegen is ongoing. Current research focuses on improving the drug's formulation and delivery, as well as exploring its potential use in treating other conditions, such as sepsis and mitochondrial diseases.
See also[edit | edit source]
Drug groups | Encyclopedia | Dictionary | Cancer drugs | OTC | Alternative meds | Drugs | Medications A-Z | FDA approved products | Portal:Pharmacology
| Fields | |
|---|---|
| Concepts | |
| Treatments | |
| Incidents | |
| Related topics | |
 | This pharmacology-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
