Zarnestra
Zarnestra (also known as Tipifarnib) is a farnesyltransferase inhibitor that is being studied in the treatment of cancer. It is a type of antineoplastic agent.
Mechanism of Action[edit | edit source]
Zarnestra works by inhibiting the enzyme farnesyltransferase, an important player in the Ras signaling pathway. This pathway is often overactive in cancer cells, leading to uncontrolled cell growth and division. By inhibiting farnesyltransferase, Zarnestra prevents the activation of the Ras protein, thereby slowing or stopping the growth of cancer cells.
Clinical Trials[edit | edit source]
Zarnestra has been studied in a number of clinical trials for various types of cancer. These include acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and colorectal cancer. While results have been mixed, some studies have shown promise, particularly in patients with certain genetic mutations.
Side Effects[edit | edit source]
Like all chemotherapy drugs, Zarnestra can cause side effects. These may include nausea, vomiting, diarrhea, and fatigue. More serious side effects can include neutropenia (a decrease in the number of white blood cells), thrombocytopenia (a decrease in the number of platelets), and anemia (a decrease in the number of red blood cells).
See Also[edit | edit source]
| Zarnestra Resources | |
|---|---|
 |
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
