Atamestane

Atamestane

Atamestane is a steroidal aromatase inhibitor that is used in the treatment of breast cancer. It is classified as a Type I aromatase inhibitor, which means it permanently binds to the aromatase enzyme and prevents it from synthesizing estrogens.

Pharmacology

Atamestane works by inhibiting the aromatase enzyme, which is responsible for the conversion of androgens to estrogens in the body. This results in a decrease in estrogen levels, which can slow the growth of certain types of breast tumors that require estrogen to grow. Atamestane is a steroidal aromatase inhibitor, which means it is structurally similar to the natural substrate of the aromatase enzyme, androstenedione. This allows it to bind permanently to the enzyme and inhibit its activity.

Clinical Use

Atamestane is used in the treatment of hormone receptor-positive breast cancer. It is typically used in postmenopausal women who have already been treated with other hormone therapies, such as tamoxifen. Atamestane may also be used in premenopausal women with breast cancer who have not responded to other treatments.

Side Effects

Common side effects of Atamestane include hot flashes, nausea, vomiting, and fatigue. Less common side effects can include osteoporosis, joint pain, and mood changes. As with all medications, patients should discuss potential side effects with their healthcare provider before starting treatment.

Research

Research into the use of Atamestane is ongoing. Some studies suggest that it may be effective in treating other types of cancer, such as prostate cancer, although more research is needed in this area.

See Also

• Aromatase inhibitor
• Breast cancer
• Hormone therapy