From WikiMD's Wellness Encyclopedia

What is Cenegermin?[edit | edit source]

What are the uses of this medicine?[edit | edit source]

How does this medicine work?[edit | edit source]

  • Nerve growth factor is an endogenous protein involved in the differentiation and maintenance of neurons, which acts through specific high-affinity (i.e., TrkA) and low-affinity (i.e. p75NTR) nerve growth factor receptors in the anterior segment of the eye to support corneal innervation and integrity.

Who Should Not Use this medicine ?[edit | edit source]

  • This medicine have no usage limitations.

What drug interactions can this medicine cause?[edit | edit source]

  • No clinically important drug interactions have been observed with Oxervate.

Is this medicine FDA approved?[edit | edit source]

  • It was approved for use in the United States in 2018.

How should this medicine be used?[edit | edit source]

  • Contact lenses should be removed before applying Oxervate and may be reinserted 15 minutes after administration.

Recommended Dosage

  • Instill one drop of Oxervate in the affected eye(s), 6 times a day at 2-hour intervals for eight weeks.


  • Use Oxervate exactly as your doctor tells you.
  • Use 1 drop of Oxervate in the affected eye or both eyes if needed, 6 times each day, about 2 hours apart starting in the morning. Continue your treatment for 8 weeks.
  • If you use any other eye drops, wait at least 15 minutes before or after using Oxervate. This will help to avoid one eye drop diluting the other eye drop.
  • If you also use an eye ointment or gel or an eye drop that is thick, use Oxervate first, and then wait at least 15 minutes before using the other eye ointment, gel, or drops.
  • If you wear contact lenses in your affected eye or both eyes remove them before using Oxervate and wait 15 minutes after using Oxervate before reinserting them.
  • If you miss a dose of Oxervate, take your next dose at your scheduled time. Do not take an extra dose to make up for a missed dose.
  • Do not use other eye medicines without talking to your doctor.
  • Talk to your doctor first before you stop using Oxervate.
  • If you have any questions about how to use Oxervate, ask your doctor or pharmacist.

What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As Ophthalmic solution: cenegermin-bkbj 0.002% (20 mcg/mL) in a multiple-dose vial.

This medicine is available in fallowing brand namesː

  • Oxervate

What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:

  • eye pain
  • enlarged blood vessels in the white of the eyes (ocular hyperemia)
  • swelling (inflammation) of the eye
  • increase of tears (increased lacrimation).

What special precautions should I follow?[edit | edit source]

  • Your vision may be blurred for a short time after using Oxervate. If this happens, wait until your vision clears before you drive or use machines.
  • Contact lenses should be removed before applying Oxervate because the presence of a contact lens (either therapeutic or corrective) could theoretically limit the distribution of cenegermin-bkbj onto the area of the corneal lesion. Lenses may be reinserted 15 minutes after administration.
  • Oxervate may cause mild to moderate eye discomfort such as eye pain during treatment. The patient should be advised to contact their doctor if a more serious eye reaction occurs.

What to do in case of emergency/overdose?[edit | edit source]

  • In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.

Can this medicine be used in pregnancy?[edit | edit source]

  • There are no data from the use of Oxervate in pregnant women to inform any drug associated risks.

Can this medicine be used in children?[edit | edit source]

  • The safety and effectiveness of Oxervate have been established in the pediatric population.

What are the active and inactive ingredients in this medicine?[edit | edit source]

  • Active ingredient: cenegermin-bkbj
  • Inactive ingredients: disodium hydrogen phosphate anhydrous, hydroxypropylmethyl cellulose, L‑methionine, mannitol, polyethylene glycol 6000, sodium dihydrogen phosphate dihydrate, trehalose dihydrate, Water for Injection, USP, and hydrochloric acid and/or sodium hydroxide to adjust pH.

Who manufactures and distributes this medicine?[edit | edit source]

Manufactured by:

Manufactured for:

  • Dompé U.S. Inc.
  • One Marina Park Drive - Ste. 1410, Boston, MA

What should I know about storage and disposal of this medication?[edit | edit source]

Pharmacy Storage

  • Store the weekly cartons in the freezer at or below -4°F (-20°C).
  • Supply the weekly cartons in an insulated pack in combination with the Delivery System Kit.

Patient Storage

  • Within 5 hours of delivery, store the weekly carton(s) containing Oxervate vials in the refrigerator between 36°F to 46°F (2°C to 8°C) for up to 14 days.
  • A vial opened for daily use may be stored in the original weekly carton in the refrigerator between 36°F to 46°F (2°C to 8°C) or at room temperature up to 77°F (25°C), for up to 12 hours .
  • Do not refreeze the vials.
  • Do not shake the vials.
  • Discard the opened vial after 12 hours even if there is still some solution left inside.
Cenegermin Resources


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