Glucagon-like peptide-2
Glucagon-like peptide-2 (GLP-2) is a protein and hormone that is synthesized and released by the intestinal cells in the human body. It is one of the two forms of Glucagon-like peptides, the other being GLP-1. GLP-2 plays a crucial role in the regulation of nutrient absorption, intestinal growth and function, and maintenance of the intestinal mucosa.
Structure[edit | edit source]
GLP-2 is a 33-amino acid peptide hormone that is derived from the proglucagon gene. The structure of GLP-2 is characterized by a single disulfide bond which is essential for its biological activity.
Function[edit | edit source]
GLP-2 is primarily known for its role in the growth and maintenance of the intestinal lining. It promotes the growth of the intestinal epithelium and enhances the absorption of nutrients by increasing the surface area of the intestinal mucosa. GLP-2 also reduces intestinal permeability and inflammation, thereby playing a role in the maintenance of gut barrier function.
In addition to its effects on the intestine, GLP-2 has been shown to influence bone metabolism, appetite regulation, and glucose homeostasis. However, the mechanisms underlying these effects are not fully understood.
Clinical significance[edit | edit source]
GLP-2 has been studied for its potential therapeutic applications in various gastrointestinal diseases. Synthetic GLP-2 analogs, such as Teduglutide, have been developed and approved for the treatment of short bowel syndrome and Crohn's disease. Research is ongoing to explore the potential of GLP-2 in the treatment of other conditions, such as intestinal failure, celiac disease, and chemotherapy-induced mucositis.
See also[edit | edit source]
 | This medical article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
