Epsilon cell

Epsilon cells are a type of endocrine cell found in the pancreatic islets of the pancreas. These cells are primarily responsible for the production and secretion of the hormone ghrelin, which plays a significant role in regulating appetite and energy balance.

Function

Epsilon cells secrete ghrelin, often referred to as the "hunger hormone." Ghrelin is a peptide hormone that stimulates appetite, increases food intake, and promotes fat storage. It is also involved in the regulation of glucose metabolism and has effects on the gastrointestinal tract.

Location

Epsilon cells are located within the pancreatic islets, also known as the islets of Langerhans. These islets are clusters of endocrine cells in the pancreas that also contain other cell types such as alpha cells, beta cells, delta cells, and PP cells.

Clinical significance

The role of epsilon cells and ghrelin in metabolic disorders such as obesity and type 2 diabetes is an area of active research. Alterations in ghrelin levels have been associated with eating disorders and weight regulation issues.

See also

• Pancreatic islets
• Endocrine system
• Ghrelin
• Appetite regulation