Non-specific interstitial pneumonia
Non-specific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia.
Symptoms[edit | edit source]
Symptoms include cough, difficulty breathing, and fatigue.[1]
Causes[edit | edit source]
It has been suggested that idiopathic nonspecific interstitial pneumonia has an autoimmune mechanism, and is a possible complication of undifferentiated connective tissue disease[2], however not enough research has been done at this time to find a cause. Patients with NSIP will often have other unrelated lung diseases like COPD or emphysema, along with other auto-immune disorders.
Diagnosis[edit | edit source]
A full clinical diagnosis can only be made from a lung biopsy of the tissue, fully best performed by a VATS, done by a cardio-thoracic surgeon. Some pulmonologists may first attempt a bronchoscopy, however this frequently fails to give a full or correct diagnosis.
Lung biopsies performed on patients with NSIP reveal two different disease patterns - cellular and fibrosing - which are associated with different prognoses. The cellular pattern displays chronic inflammation with minimal fibrosis. The fibrosing pattern displays interstitial fibrosis with various inflammation levels. Both patterns are uniform and lack the prominent fibroblastic foci that are found in other types of idiopathic interstitial pneumonia.[3]
Treatment[edit | edit source]
Commonly used drugs include prednisone, imuran, and cellcept. For active cases of pneumonia for these patients, Levaquin is a commonly used antibiotic. Almost all patients with NSIP will be on oxygen.
Prognosis[edit | edit source]
The fibrosing pattern of NSIP has a five year survival rate of 86% to 92%, while the cellular pattern of NSIP has a 100% five year survival rate. Patients with NSIP(whether cellular or fibrosing), have a better prognosis than those with usual interstitial pneumonia (UIP).[4]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
