Prucalopride succinate

Prucalopride Succinate is a pharmaceutical drug used primarily for the treatment of chronic constipation. It is a selective, high affinity serotonin (5-HT4) receptor agonist that stimulates colonic peristalsis, increasing bowel motility.

Pharmacology

Prucalopride succinate works by stimulating the 5-HT4 receptors in the enteric nervous system in the gastrointestinal tract. This leads to an increase in the release of acetylcholine, which in turn increases the motility of the colon, facilitating bowel movements.

Clinical Use

Prucalopride succinate is used for the treatment of chronic constipation in adults for whom laxatives have not provided adequate relief. It is also used in the management of Opioid-induced constipation.

Side Effects

Common side effects of prucalopride succinate include headache, nausea, diarrhea, and abdominal pain. In rare cases, it can cause serious side effects such as arrhythmia and hypersensitivity reactions.

Contraindications

Prucalopride succinate is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe renal impairment or end-stage renal disease.

Interactions

Prucalopride succinate may interact with other drugs such as ketoconazole, erythromycin, and diltiazem, which can affect its metabolism and efficacy.

Dosage

The recommended dosage of prucalopride succinate is 2 mg once daily. The dose may be reduced to 1 mg once daily for patients with severe liver impairment.

See Also

• Chronic constipation
• 5-HT4 receptor
• Enteric nervous system
• Opioid-induced constipation