Recombinant human nerve growth factor
Recombinant Human Nerve Growth Factor
The Recombinant Human Nerve Growth Factor (rhNGF) is a protein that is crucial for the growth, maintenance, and survival of certain nerve cells (neurons). It is a type of neurotrophin released by cells that helps to stimulate and control neurogenesis, the process of nerve cell growth and development.
Structure and Function[edit | edit source]
The rhNGF is a dimer composed of two identical 118 amino acid subunits, which are held together by disulfide bridges. The protein is encoded by the NGF gene, which is located on chromosome 1 in humans.
The primary role of rhNGF is to promote the survival and differentiation of neurons, particularly sensory and sympathetic neurons. It achieves this by binding to and activating the TrkA receptor, a type of tyrosine kinase receptor found on the surface of these neurons.
Clinical Significance[edit | edit source]
Due to its role in nerve growth and maintenance, rhNGF has been studied for potential therapeutic applications in a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. It has also been investigated for use in the treatment of peripheral neuropathy, a condition that results in the damage to the peripheral nerves.
See Also[edit | edit source]
References[edit | edit source]
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