7-Chlorokynurenic acid

7-Chlorokynurenic acid (7-CKA) is a pharmacological agent known for its role as an antagonist at the N-methyl-D-aspartate receptor (NMDAR), a type of ionotropic glutamate receptor. It is a derivative of kynurenic acid, a known NMDAR antagonist produced in the human body.

Chemistry

7-Chlorokynurenic acid is a chlorinated derivative of kynurenic acid. The addition of a chlorine atom at the 7 position of the kynurenic acid molecule enhances its antagonistic activity at the NMDAR.

Pharmacology

7-Chlorokynurenic acid acts as a potent and selective antagonist at the glycine site of the NMDAR. This site is a critical component of the receptor's function, as glycine binding is necessary for the receptor to become activated by glutamate, the primary excitatory neurotransmitter in the human brain.

Therapeutic Potential

Due to its ability to modulate NMDAR activity, 7-Chlorokynurenic acid has been investigated for potential therapeutic applications in conditions characterized by excessive or abnormal glutamate activity. These include neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, as well as psychiatric disorders like schizophrenia and major depressive disorder.

Safety and Toxicity

While 7-Chlorokynurenic acid has shown promise in preclinical studies, its safety and toxicity profile in humans is not yet fully understood. Further research is needed to determine the potential risks and benefits of this compound in a clinical setting.

See Also

• Kynurenic acid
• NMDA receptor antagonist
• Neurodegenerative diseases
• Schizophrenia
• Major depressive disorder

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