Bempedoic acid

What is Bempedoic acid?[edit | edit source]

Bempedoic acid (Nexletol) is an adenosine triphosphate-citrate lyase (ACL) inhibitor.

This medicine is used along with diet and other lipid-lowering medicines in the treatment of adults with:

heterozygous familial hypercholesterolemia (HeFH). HeFH is an inherited condition that causes high levels of "bad" cholesterol called low density lipoprotein (LDL).
known heart disease who need additional lowering of "bad" cholesterol (LDL-C) levels.

Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibition of cholesterol synthesis in the liver.
Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP15228-CoA, respectively.
ACSVL1 is expressed primarily in the liver.
Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of low-density lipoprotein receptors.

Limitation of use:

It is not known if Nexletol can decrease problems from high cholesterol, such as heart attacks, stroke, death, or other heart problems.
It is not known if Nexletol is safe and effective in people with severe kidney problems including people with end-stage kidney disease who are on dialysis.
It is not known if Nexletol is safe and effective in people with severe liver problems.
It is not known if Nexletol is safe and effective in children under 18 years of age.

Recommended Dosage

The recommended dosage of Nexletol, in combination with maximally tolerated statin therapy, is 180 mg administered orally once daily. Nexletol can be taken with or without food.
After initiation of Nexletol, analyze lipid levels within 8 to 12 weeks.

Administration

Take Nexletol exactly as your healthcare provider tells you to take it. Check with your healthcare provider or pharmacist if you are not sure.
Take 1 Nexletol tablet by mouth each day.
You may take Nexletol with or without food.
If you take too much Nexletol, call your poison control center at 1-800-222-1222 or go to the nearest hospital emergency room right away.

This medicine is available in fallowing doasage form:

This medicine is available in fallowing brand namesː

The most common side effects of this medicine include:

Nexletol may cause serious side effects, including:

This medicine may cause hyperuricemia. Assess uric acid levels periodically as clinically indicated. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate.
This medicine may cause tendon rupture. Discontinue Nexletol at the first sign of tendon rupture. Avoid Nexletol in patients who have a history of tendon disorders or tendon rupture.

In the event of an overdosage, contact Poison Control (1-800-222-1222) for latest recommendations.

There are no available data on Nexletol use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.

The safety and effectiveness of Nexletol have not been established in pediatric patients.

Store Nexletol in the original package at room temperature between 68°F to 77°F (20°C to 25°C).
Do not throw away the packet that helps to keep your medicine dry (desiccant).

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