Lisinopril + HCTZ

What Is Lisinopril + HCTZ

Lisinopril and hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure.

What are the uses of this medicine?

• The combination of lisinopril and hydrochlorothiazide is used to treat high blood pressure.
• Lisinopril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors.
• It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly.
• Hydrochlorothiazide is in a class of medications called diuretics ('water pills').
• It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.

Who Should Not Use Lisinopril + HCTZ  ?

• ZESTORETIC is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an angiotensin-converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema.
• Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs.

Is this medicine FDA approved

• The combination was approved for medical use in the United States in 1989.
• It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.
• In 2018, it was the 51st most commonly prescribed medication in the United States, with more than 15 million prescriptions.

How should this medicine be used?

Lisinopril and hydrochlorothiazide tablets are available for oral use in three tablet combinations of lisinopril with hydrochlorothiazide: lisinopril and hydrochlorothiazide tablets, 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg.

What are the dosage forms and brand names of this medicine?

Lisinopril monotherapy is an effective treatment of hypertension in once-daily doses of 10 mg to 80 mg, while hydrochlorothiazide monotherapy is effective in doses of 12.5 mg per day to 50 mg per day.

This medicine is available under brand names:

• Prinzide®
• Zestoretic®

What side effects can this medication cause?

Common possible side effects of this medicine include:

• heartburn
• headache
• dizziness
• excessive tiredness
• cough
• decrease in sexual ability
• pain, burning, or tingling in the hands or feet

Some serious side effects may include:

• stomach pain
• hoarseness
• difficulty breathing or swallowing
• vomiting
• upset stomach
• yellowing of the skin or eyes
• fever, sore throat, chills, and other signs of infection
• muscle pain, cramps, or weakness
• fainting
• dry mouth
• thirst
• weakness
• restlessness
• confusion
• seizures
• decrease in urination
• lightheadedness
• chest pain
• rapid, pounding, slow, or irregular heartbeat
• pain in big toe
• tingling in arms and legs
• loss of muscle tone
• weakness or heaviness in legs
• lack of energy
• cold, gray skin
• swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

What to do in case of emergency/overdose?

• No specific information is available on the treatment of overdosage with lisinopril and hydrochlorothiazide.
• Treatment is symptomatic and supportive.
• Therapy with lisinopril and hydrochlorothiazide should be discontinued and the patient observed closely.
• Suggested measures include induction of emesis and/or gastric lavage, and correction of dehydration, electrolyte imbalance and hypotension by established procedures.

Symptoms of overdose may include:

• lightheadedness
• dry mouth
• blurred vision
• Fianting
• thirst
• drowsiness
• weakness
• seizures
• restlessness
• infrequent urination
• muscle pains or cramps
• vomiting
• upset stomach
• confusion
• rapid or pounding heartbeat

Can this medicine be used in pregnency?

• When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus.
• When pregnancy is detected, Lisinopril and hydrochlorothiazide should be discontinued as soon as possible.

Can this medicine be used for Pediatrics?

• Safety and effectiveness in pediatric patients have not been established.

What should I know about storage and disposal of this medication?

• Keep this medication in the container it came in, tightly closed, and out of reach of children.
• Store it at room temperature and away from excess heat and moisture (not in the bathroom).

‎

• Dailymed label info on Lisinopril + HCTZ
• FDA Lisinopril + HCTZ

Lisinopril + HCTZ Resources
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