Irbesartan/hydrochlorothiazide

Irbesartan/hydrochlorothiazide is a combination medication used in the treatment of high blood pressure. It combines two active ingredients, irbesartan and hydrochlorothiazide, which work together to lower blood pressure more effectively than either medication does on its own. Irbesartan is an angiotensin II receptor antagonist, which means it helps to relax blood vessels by blocking the action of a natural substance that normally tightens blood vessels. Hydrochlorothiazide is a thiazide diuretic (also known as a water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. This combination medication is often prescribed when a single drug is not sufficient to control blood pressure.

Medical Uses

Irbesartan/hydrochlorothiazide is primarily used for the treatment of hypertension (high blood pressure). Controlling high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is usually prescribed after other blood pressure medications have been tried without successful treatment of hypertension.

How It Works

Irbesartan works by blocking the action of angiotensin II, a chemical in your body that causes blood vessels to tighten and narrow. This helps to relax and widen the blood vessels, allowing blood to flow more easily. Hydrochlorothiazide helps to reduce the amount of salt and water in the body by increasing urine output, which also helps to lower blood pressure. The combination of these two medications allows for a more comprehensive approach to managing high blood pressure.

Side Effects

Common side effects of irbesartan/hydrochlorothiazide include dizziness, lightheadedness, or upset stomach. These effects are usually temporary and may disappear as your body adjusts to the medication. Serious side effects are rare but can include fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), or signs of kidney problems (such as change in the amount of urine). It is important to contact a healthcare provider immediately if any of these serious side effects occur.

Precautions

Before taking irbesartan/hydrochlorothiazide, patients should inform their doctor or pharmacist if they are allergic to it; or if they have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. It is also important to discuss your medical history, especially of kidney disease, liver disease, dehydration, and electrolyte imbalances.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.