Progressive encephalomyelitis with rigidity and myoclonus
Other Names: PERM Progressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare and severe neurological syndrome characterized by muscular rigidity and spasms as well as brain stem and autonomic dysfunction. It can be associated with anti-GAD, GlyR, and DPPX antibodies. All of these autoantibodies may be variably associated with malignant tumors and their response to immunotherapy, as well as to tumor removal, is not easily predictable.
NIH genetic and rare disease info[edit source]
Progressive encephalomyelitis with rigidity and myoclonus is a rare disease.
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