3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid

Overview

3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid, commonly abbreviated as CPP, is a synthetic compound that acts as a selective antagonist of the NMDA receptor. It is primarily used in scientific research to study the role of NMDA receptors in the central nervous system and their involvement in various neurological processes and disorders.

Chemical Structure

The chemical structure of 3-(2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid consists of a piperazine ring substituted with a carboxylic acid group and a propyl phosphonic acid moiety. The IUPAC name for CPP is 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid, and its molecular formula is C8H15N2O6P.

Mechanism of Action

CPP functions as an antagonist at the NMDA receptor, a type of glutamate receptor that plays a crucial role in synaptic plasticity, memory function, and neurodevelopment. By binding to the receptor, CPP inhibits the action of glutamate, the primary excitatory neurotransmitter in the brain, thereby modulating synaptic transmission and neuronal excitability.

Applications in Research

CPP is widely used in neuropharmacological research to investigate the physiological and pathological roles of NMDA receptors. It is particularly valuable in studies related to:

• Neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
• Epilepsy and seizure disorders.
• Stroke and ischemic brain injury.
• Chronic pain and neuropathic pain.

Safety and Handling

As with many research chemicals, proper safety protocols should be followed when handling CPP. It should be used in a controlled laboratory environment, and researchers should wear appropriate personal protective equipment (PPE) to minimize exposure.

Also see

• NMDA receptor
• Glutamate receptor
• Neurotransmitter
• Synaptic plasticity
• Neuropharmacology