CP-96345

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CP-96345 is a chemical compound that acts as a potent and selective antagonist of the neurokinin 1 receptor (NK1 receptor). It is primarily used in scientific research to study the role of substance P and NK1 receptors in various physiological and pathological processes.

Mechanism of Action

CP-96345 functions by competitively inhibiting the binding of substance P, a neuropeptide, to the NK1 receptor. Substance P is involved in the transmission of pain and other sensory signals in the central nervous system. By blocking this receptor, CP-96345 can modulate pain perception and has potential therapeutic implications in conditions such as chronic pain, depression, and anxiety disorders.

Pharmacological Properties

CP-96345 is characterized by its high affinity for the NK1 receptor, with a Ki value in the low nanomolar range. It exhibits selectivity over other neurokinin receptors, such as NK2 and NK3, making it a valuable tool for dissecting the specific roles of NK1 receptor-mediated pathways.

Research Applications

CP-96345 has been extensively used in preclinical studies to explore the involvement of NK1 receptors in various biological processes. It has been instrumental in:

• Investigating the role of substance P in pain management and nociception.
• Studying the effects of NK1 receptor antagonism in psychiatric disorders such as depression and anxiety.
• Exploring the potential of NK1 receptor antagonists in chemotherapy-induced nausea and vomiting (CINV).

Safety and Toxicology

While CP-96345 is primarily used in research settings, its safety profile has been evaluated in animal models. It is generally well-tolerated at doses used in experimental studies, but detailed toxicological data are limited.

Also see

• Neurokinin 1 receptor
• Substance P
• Pain management
• NK1 receptor antagonists

References

Template:Receptor antagonists Template:Neuropharmacology