GATA4
GATA4 is a gene that encodes a protein known as GATA binding protein 4. This protein is a member of the GATA family of transcription factors, which play a crucial role in cellular development and differentiation. GATA4, in particular, is involved in the development and function of the heart and digestive system.
Function[edit | edit source]
GATA4 is a transcription factor, meaning it binds to specific regions of DNA and regulates the activity of other genes. It is involved in the development of several organs, including the heart and digestive system. In the heart, GATA4 helps regulate the growth and differentiation of cardiac muscle cells. In the digestive system, it is involved in the development of the stomach, liver, and pancreas.
Clinical significance[edit | edit source]
Mutations in the GATA4 gene have been associated with several congenital heart defects, including atrial septal defect and ventricular septal defect. These conditions occur when the wall that separates the heart's left and right sides does not form correctly. GATA4 mutations can also cause tetralogy of Fallot, a complex heart defect that affects blood flow through the heart.
In addition to heart defects, GATA4 mutations have been linked to pancreatic agenesis, a condition in which the pancreas fails to develop. This can lead to diabetes and other health problems.
Research[edit | edit source]
Research on GATA4 is ongoing, with scientists seeking to better understand its role in organ development and disease. Some studies are exploring the potential of using GATA4 to regenerate heart tissue after a heart attack, while others are investigating its role in cancer.
See also[edit | edit source]
Cardiovascular disease A-Z
Most common cardiac diseases
- Cardiac arrhythmia
- Cardiogenetic disorders
- Cardiomegaly
- Cardiomyopathy
- Cardiopulmonary resuscitation
- Chronic rheumatic heart diseases
- Congenital heart defects
- Heart neoplasia
- Ischemic heart diseases
- Pericardial disorders
- Syndromes affecting the heart
- Valvular heart disease
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
A[edit source]
- Accelerated idioventricular rhythm
- Acute decompensated heart failure
- Arteriosclerotic heart disease
- Athletic heart syndrome
- Atrial flutter
- Atrioventricular fistula
- Cardiovascular disease in Australia
- Autoimmune heart disease
B[edit source]
C[edit source]
- Ebb Cade
- Cardiac allograft vasculopathy
- Cardiac amyloidosis
- Cardiac asthma
- Cardiac tamponade
- Cardiogenic shock
- Cardiogeriatrics
- Cardiorenal syndrome
- Cardiotoxicity
- Carditis
- Coronary artery aneurysm
- Coronary artery anomaly
- Coronary artery disease
- Spontaneous coronary artery dissection
- Coronary artery ectasia
- Coronary occlusion
- Coronary steal
- Coronary thrombosis
- Coronary vasospasm
- Cœur en sabot
- Coxsackievirus-induced cardiomyopathy
D[edit source]
E[edit source]
H[edit source]
- Heart attack
- Heart failure
- Heart failure with preserved ejection fraction
- Heart to Heart (1949 film)
- High-output heart failure
- Hyperdynamic precordium
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
I[edit source]
- Idiopathic giant-cell myocarditis
- Interventricular dyssynchrony
- Intraventricular dyssynchrony
- Isolated atrial amyloidosis
K[edit source]
L[edit source]
M[edit source]
- Mydicar
- Myocardial bridge
- Myocardial disarray
- Myocardial rupture
- Myocardial scarring
- Myocardial stunning
- Myocarditis
N[edit source]
O[edit source]
P[edit source]
- Papillary fibroelastoma
- Pathophysiology of heart failure
- Postpericardiotomy syndrome
- Pulmonary vein stenosis
R[edit source]
S[edit source]
- Saturated fat and cardiovascular disease
- SCAR-Fc
- Shone's syndrome
- Strain pattern
- Subacute bacterial endocarditis
- Sudden cardiac death of athletes
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
T[edit source]
V[edit source]
W[edit source]
| Health science - Medicine - Gastroenterology - edit |
|---|
| Diseases of the esophagus - stomach |
| Halitosis | Nausea | Vomiting | GERD | Achalasia | Esophageal cancer | Esophageal varices | Peptic ulcer | Abdominal pain | Stomach cancer | Functional dyspepsia | Gastroparesis |
| Diseases of the liver - pancreas - gallbladder - biliary tree |
| Hepatitis | Cirrhosis | NASH | PBC | PSC | Budd-Chiari | Hepatocellular carcinoma | Acute pancreatitis | Chronic pancreatitis | Pancreatic cancer | Gallstones | Cholecystitis |
| Diseases of the small intestine |
| Peptic ulcer | Intussusception | Malabsorption (e.g. Coeliac, lactose intolerance, fructose malabsorption, Whipple's) | Lymphoma |
| Diseases of the colon |
| Diarrhea | Appendicitis | Diverticulitis | Diverticulosis | IBD (Crohn's, Ulcerative colitis) | IBS | Constipation | Colorectal cancer | Hirschsprung's | Pseudomembranous colitis |
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Contributors: Prab R. Tumpati, MD
