Lambert–Eaton syndrome
Lambert–Eaton syndrome (LES), also known as Lambert–Eaton myasthenic syndrome (LEMS), is a rare autoimmune disorder characterized by muscle weakness of the limbs. It is caused by a disruption in the normal functioning of nerve cells in the peripheral nervous system.
Etiology[edit | edit source]
The primary cause of Lambert–Eaton syndrome is an autoimmune reaction where the body's immune system mistakenly attacks the nerve cells. This is often associated with certain types of cancer, particularly small cell lung cancer, which is found in about 50% of all cases. However, in some cases, the cause of LES is unknown, and these are classified as idiopathic.
Symptoms[edit | edit source]
The main symptom of Lambert–Eaton syndrome is muscle weakness, which typically affects the muscles of the legs before the arms or hands. Other symptoms can include dry mouth, constipation, impotence in men, and changes in vision. The severity and range of symptoms can vary greatly from person to person.
Diagnosis[edit | edit source]
Diagnosis of Lambert–Eaton syndrome is typically based on a combination of clinical symptoms and diagnostic tests. These tests can include electromyography (EMG), which measures the electrical activity of muscles, and blood tests to detect the presence of specific antibodies associated with LES.
Treatment[edit | edit source]
Treatment for Lambert–Eaton syndrome primarily involves managing the symptoms and, if applicable, treating the underlying cancer. Medications can be used to improve muscle strength and reduce fatigue, and physical therapy may also be beneficial.
Prognosis[edit | edit source]
The prognosis for individuals with Lambert–Eaton syndrome can vary greatly depending on the severity of the symptoms and the presence of underlying cancer. However, with appropriate treatment, most individuals with LES can lead a normal life.
See also[edit | edit source]
| This Neuromuscular diseases article is a stub. | |
|---|---|
| Disorders | Amyotrophic lateral sclerosis • Muscular dystrophy • Myasthenia gravis • Spinal muscular atrophy • Charcot-Marie-Tooth disease • Multiple sclerosis • Peripheral neuropathy • Polymyositis • Dermatomyositis |
| Diagnosis and Treatment | Electromyography • Muscle biopsy • Physical therapy • Occupational therapy • Speech therapy • Immunosuppressive therapy • Gene therapy |
| Related Articles | Neurology • Orthopedics • Physical medicine and rehabilitation • Genetic disorder • Autoimmune disease |
| Organizations | World Health Organization • National Institute of Neurological Disorders and Stroke • Muscular Dystrophy Association • ALS Association |
NIH genetic and rare disease info[edit source]
Lambert–Eaton syndrome is a rare disease.
| Lambert–Eaton syndrome Resources | |
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