Zanamivir
From WikiMD's WELLNESSPEDIA
(Redirected from Relenza)
Zanamivir is a substance that is being studied in the treatment of prostate cancer.
Class[edit]
It belongs to the family of drugs called endothelin-receptor antagonists.
Information about Zanamivir[edit]
- Zanamivir is an inhibitor of the influenza neuramidase enzyme and is given by inhalation as therapy and prophylaxis against influenza A and B.
- Zanamivir may be used to treat and prevent infections from influenza A (H1N1).
Liver safety of Zanamivir[edit]
Zanamivir has not been associated with clinically apparent liver injury, at least when given by inhalation.
Mechanism of action of Zanamivir[edit]
- Zanamivir (za nam' i vir) is a sialic acid analogue and a potent inhibitor of the neuraminidase of influenza viruses.
- Inhibition of this enzyme causes a decrease in viral replication, probably as a result of interference with particle formation and release. Zanamivir is active against both influenza A and B viruses, but has no activity against other common upper respiratory tract viruses.
- In addition, resistance to zanamivir can develop rapidly.
- Zanamivir is indicated for therapy or post-exposure prevention of influenza A or B.
FDA approval information for Zanamivir[edit]
- Zanamivir was approved in the United States in 1999 and is frequently used during influenza outbreaks.
- Zanamivir is available as a powder for inhalation (5 mg/blister pack) under the brand name of Relenza.
Dose[edit]
- The recommended dose for therapy in adults is 2 oral inhalations of 5 mg each, twice daily for 5 days;
- the usual prophylactic regimen is 10 mg once daily for 10 days, starting within 2 days of close contact with an infected person or for 28 days in a community setting.
Side effects of Zanamivir[edit]
Side effects are uncommon and include mild nausea, dizziness, headache, cough, nasal and throat irritation and bronchospasm.
More serious side effects[edit]
- difficulty breathing
- wheezing
- shortness of breath
- hives
- rash
- itching
- difficulty swallowing
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- hoarseness
Brand names[edit]
Relenza®
Step by step instructions[edit]
Cost[edit]
- The lowest GoodRx price for the most common version of Relenza is around $69.40, 9% off the average retail price of $76.28.
External links[edit]
- Relenza: Consumer Questions and Answers US Food and Drug Administration (FDA)
- Relenza web site GlaxoSmithKline
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