SNAP-5114

SNAP-5114 is a chemical compound that acts as a selective inhibitor of the GABA transporter 3 (GAT-3). It is primarily used in scientific research to study the role of GAT-3 in the central nervous system (CNS) and its potential implications in various neurological disorders.

Mechanism of Action

SNAP-5114 functions by inhibiting the reuptake of gamma-aminobutyric acid (GABA) into astrocytes and neurons, thereby increasing the extracellular concentration of GABA. This action enhances GABAergic neurotransmission, which can have various effects on neuronal excitability and synaptic plasticity.

Pharmacological Effects

The inhibition of GAT-3 by SNAP-5114 has been shown to modulate seizure activity in animal models, suggesting potential therapeutic applications in epilepsy. Additionally, SNAP-5114 has been used to investigate the role of GABAergic signaling in anxiety, depression, and other mood disorders.

Research Applications

SNAP-5114 is widely used in neuroscience research to:

• Study the distribution and function of GAT-3 in the brain.
• Investigate the role of GABA transporters in synaptic transmission and neurotransmitter regulation.
• Explore potential therapeutic targets for neurological disorders involving dysregulated GABAergic signaling.

Safety and Toxicology

As a research chemical, SNAP-5114 is not approved for human use. Studies on its safety profile are limited to preclinical models, where it has been generally well-tolerated at doses used in experimental settings. However, comprehensive toxicological data are lacking.

Also see

• GABA transporter 1
• GABA transporter 2
• GABA transporter 4
• GABA receptor
• Neurotransmitter transporters

References

Template:GABAergic drugs Template:Neuropharmacology