Sporanox

Sporanox (also known as Itraconazole) is a triazole antifungal medication used to treat a variety of fungal infections. It is produced by Janssen Pharmaceutica, a pharmaceutical company based in Belgium.

Indications

Sporanox is primarily used to treat a range of fungal infections, including blastomycosis, histoplasmosis, aspergillosis, and onychomycosis. It is also used in the treatment of candidiasis, particularly in patients who are immunocompromised.

Mechanism of Action

Sporanox works by inhibiting the fungal cytochrome P-450 enzyme. This prevents the conversion of lanosterol to ergosterol, disrupting the synthesis of the fungal cell membrane.

Side Effects

Common side effects of Sporanox include nausea, vomiting, diarrhea, rash, and edema. More serious side effects can include liver damage, heart failure, and negative interactions with other medications.

Contraindications

Sporanox is contraindicated in patients with known hypersensitivity to itraconazole. It should also not be used in patients with congestive heart failure or with a history of liver disease.

Interactions

Sporanox can interact with a number of other medications, including certain antacids, antihistamines, and antiretrovirals. It is important for patients to inform their healthcare provider of all medications they are currently taking.

See Also

• Antifungal medication
• Triazole

References

Sporanox Resources
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