Adekalant

An overview of the pharmaceutical compound Adekalant

Adekalant is a pharmaceutical compound that has been studied for its potential therapeutic effects in various medical conditions. It is primarily known for its role as a potassium channel blocker, which can influence cardiac electrophysiology and potentially be used in the treatment of cardiac arrhythmias.

Pharmacology

Adekalant functions by blocking specific types of potassium channels in the heart. Potassium channels are crucial for the repolarization phase of the cardiac action potential. By inhibiting these channels, Adekalant can prolong the action potential duration and refractory period, which may help in stabilizing abnormal heart rhythms.

Mechanism of Action

The primary mechanism of action of Adekalant involves the inhibition of the I_Kr current, which is a component of the delayed rectifier potassium current. This action results in the prolongation of the cardiac action potential and can be beneficial in conditions such as atrial fibrillation and ventricular tachycardia.

Clinical Applications

Adekalant has been investigated in clinical trials for its efficacy in treating various types of cardiac arrhythmias. However, its development has been limited due to concerns about potential proarrhythmic effects, which are a common issue with drugs that prolong the QT interval.

Side Effects

The use of Adekalant can be associated with several side effects, primarily related to its effects on cardiac electrophysiology. These may include:

• Prolonged QT interval: This can increase the risk of torsades de pointes, a potentially life-threatening form of ventricular tachycardia.
• Dizziness and fatigue: Common side effects due to its systemic effects.
• Gastrointestinal disturbances: Such as nausea and vomiting.

Research and Development

Research into Adekalant has focused on its potential benefits and risks in the treatment of cardiac arrhythmias. Ongoing studies aim to better understand its safety profile and to identify patient populations that may benefit most from its use.

Also see

• Potassium channel blockers
• Cardiac arrhythmia
• QT interval
• Torsades de pointes

Cardiovascular disease A-Z

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A

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• Athletic heart syndrome
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• Cardiovascular disease in Australia
• Autoimmune heart disease

B

• Brown atrophy of the heart

C

• Ebb Cade
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D

• Duke Treadmill Score
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E

• Eisenmenger's syndrome
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H

• Heart attack
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I

• Idiopathic giant-cell myocarditis
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K

• Keshan disease

L

• Loeffler endocarditis

M

• Mydicar
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N

• Nonbacterial thrombotic endocarditis

O

• OLR1
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P

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R

• Right axis deviation
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T

• Traumatic cardiac arrest

V

• Ventricular aneurysm
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W

• Waon therapy