Aprikalim

From WikiMD's Wellness Encyclopedia

An article about the pharmaceutical drug Aprikalim


{{Drugbox | Verifiedfields = changed | verifiedrevid = 123456789 | IUPAC_name = (2R)-2-[(2S)-2-[[4-(1H-pyrrol-1-yl)butyl]amino]-1-hydroxyethyl]pyrrolidine-1-carbonitrile | image = | width = 200 | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = | pregnancy_US = | legal_AU = | legal_CA = | legal_UK = | legal_US = | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 123456-78-9 | ATC_prefix = | ATC_suffix = | PubChem = 123456 | DrugBank = DB12345 | ChemSpiderID = 123456 | UNII = 123456789A | KEGG = D12345 | ChEBI = 12345 | ChEMBL = 1234567 | synonyms = }}

Aprikalim is a pharmaceutical drug that acts as a potassium channel opener. It is primarily used in the treatment of hypertension and certain types of angina. Aprikalim works by relaxing the smooth muscle in blood vessels, leading to vasodilation and a subsequent decrease in blood pressure.

Mechanism of Action[edit | edit source]

Aprikalim functions by opening ATP-sensitive potassium channels in the smooth muscle cells of blood vessels. This action leads to hyperpolarization of the cell membrane, which reduces the influx of calcium ions. As a result, the smooth muscle relaxes, causing vasodilation and a reduction in blood pressure.

Pharmacokinetics[edit | edit source]

The pharmacokinetic profile of Aprikalim includes its absorption, distribution, metabolism, and excretion. It is administered orally and has a variable bioavailability. The drug is metabolized in the liver and has a half-life that allows for dosing once or twice daily, depending on the therapeutic needs of the patient.

Clinical Uses[edit | edit source]

Aprikalim is used in the management of:

  • Hypertension: As a vasodilator, Aprikalim is effective in lowering high blood pressure.
  • Angina: It can be used to relieve chest pain associated with angina by improving blood flow to the heart muscle.

Side Effects[edit | edit source]

Common side effects of Aprikalim include:

  • Headache
  • Dizziness
  • Flushing
  • Nausea

Serious side effects may include:

  • Hypotension
  • Tachycardia

Contraindications[edit | edit source]

Aprikalim is contraindicated in patients with:

  • Severe hypotension
  • Known hypersensitivity to the drug

Interactions[edit | edit source]

Aprikalim may interact with other antihypertensive agents, leading to an additive effect on blood pressure reduction. Caution is advised when used in combination with other drugs that affect potassium levels.

Research and Development[edit | edit source]

Research is ongoing to explore additional therapeutic uses of Aprikalim, including its potential role in treating other cardiovascular conditions.

Also see[edit | edit source]


Cardiovascular disease A-Z

Most common cardiac diseases

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Contributors: Prab R. Tumpati, MD