Cocaine

Engineered Monoclonal Antibodies

Diagram of engineered monoclonal antibodies

Engineered monoclonal antibodies are a class of biological therapies that are designed to target specific antigens on the surface of cells. These antibodies are produced using recombinant DNA technologies and are used in the treatment of various diseases, including cancer, autoimmune disorders, and infectious diseases.

Structure and Function

Monoclonal antibodies are composed of two identical heavy chains and two identical light chains, forming a Y-shaped molecule. The tips of the "Y" contain the antigen-binding sites, which are highly specific to the target antigen. This specificity allows monoclonal antibodies to bind to their target with high affinity, blocking or modulating the function of the antigen.

Types of Engineered Monoclonal Antibodies

There are several types of engineered monoclonal antibodies, each designed for specific therapeutic purposes:

• Chimeric antibodies: These antibodies are composed of murine (mouse) variable regions and human constant regions. They are less immunogenic than fully murine antibodies.

• Humanized antibodies: These antibodies are mostly human, with only the antigen-binding sites derived from murine sources. This reduces the risk of immune reactions.

• Fully human antibodies: These are entirely human in origin, produced using transgenic mice or phage display technologies.

• Bispecific antibodies: These antibodies are engineered to bind two different antigens simultaneously, offering unique therapeutic mechanisms.

Applications in Medicine

Engineered monoclonal antibodies have revolutionized the treatment of many diseases:

• Cancer therapy: Monoclonal antibodies can target specific tumor antigens, leading to direct tumor cell killing or recruitment of immune cells to attack the tumor.

• Autoimmune diseases: By targeting specific components of the immune system, monoclonal antibodies can reduce inflammation and tissue damage in diseases such as rheumatoid arthritis and multiple sclerosis.

• Infectious diseases: Monoclonal antibodies can neutralize pathogens or their toxins, providing passive immunity or enhancing the host's immune response.

Production

The production of engineered monoclonal antibodies involves several steps:

1. Antigen identification: The target antigen is identified and characterized. 2. Hybridoma technology: B cells from immunized animals are fused with myeloma cells to create hybridomas that produce the desired antibody. 3. Recombinant DNA technology: Genes encoding the antibody are cloned and expressed in suitable host cells, such as Chinese hamster ovary cells. 4. Purification and formulation: The antibodies are purified and formulated for clinical use.

Challenges and Future Directions

While engineered monoclonal antibodies have shown great promise, there are challenges such as high production costs, potential for immune reactions, and the development of resistance. Ongoing research aims to improve antibody design, reduce immunogenicity, and enhance therapeutic efficacy.

Related Pages

• Monoclonal antibody therapy
• Biopharmaceutical
• Immunotherapy
• Hybridoma technology

Cocaine (also cocain) is a drug that is made from coca leaves. Cocaine is usually a white powder. Most cocaine is used as an illegal drug. Because it is a stimulant, cocaine gives people energy. It also makes people feel very happy when it is taken. When used this way, cocaine is very addictive. However, cocaine can also be used as a local anesthetic if it is applied topically (onto the skin or gums).

Lines of Cocaine for snorting

Cocaine hydrochloride CII for medicinal use

Origin and effects

Where cocaine comes from

Leaves of the Coca plant

Cocaine is taken from the leaves of the coca plant. Coca plants are mostly grown in South America, in countries like Brazil or Argentina. When Spanish conquistadors (explorers) discovered coca plants, they sent them back to Europe. People started using cocaine as a medicine, as well as in drinks and food. This was because they did not know how damaging and addictive the drug could be when used.

In America, cocaine was used during surgery, or to treat toothaches. It was also put into drinks. When Coca-Cola was first made in 1885, it got the first part of its name from the "handful of coca leaves" added to the drink for energy. (The caffeine in the drink came from the kola nut, so the name "Coca-Cola" was chosen.) Cocaine was taken out of Coca-Cola completely by the 1920s because of pressure from groups in the United States.

Effects of cocaine

When cocaine is applied topically (onto the skin or gums), it causes numbness.

When cocaine is chewed or eaten, inhaled into the nose ("snorted"), or injected into the veins, it causes people to feel euphoric (very happy), alert, very confident, and full of energy. This feeling is called being "high." Some people who take cocaine also have unpleasant feelings. They may feel worried, anxious, or even paranoid. They may also have physical symptoms, like shaking, a high heart rate, and high body temperature.

Cocaine cannot be smoked in its normal form. It must react with another chemical to form crack cocaine, which can be smoked. This is because burning normal cocaine destroys it, so the user does not get the effect they want.

Cocaine as an illegal drug

Main article: Crack (drug)

Cocaine hydrochloride powder

In most countries, it is illegal to make, sell, or use cocaine (unless it is being used for approved medical reasons).

As an illegal drug, cocaine can be used in its powder form, or it can be made into crack cocaine. Usually, crack is made by adding baking soda and water to cocaine and then heating the mixture. Crack is usually less expensive than the normal form of cocaine. Crack is usually smoked. It gives users a high that is very strong, but does not last as long as the high from regular cocaine. Both forms of cocaine are addictive, although crack cocaine is thought to be more addictive as it is usually smoked.

Dangers of using cocaine

If people use cocaine, they may take too much and get sick or even die. This is called an "overdose". When people take cocaine, they get intoxicated as well. When a person is intoxicated, they may do dangerous things, such as having unsafe sex with a person they do not know, or getting into a violent fight with a person.

If a person uses cocaine for a long time, they can start to get strange feelings, like there are bugs crawling under their skin, or they can get paranoia (a feeling that there are people that want to hurt them).

Cocaine is a very addictive drug. It can lead to psychological and/or physical dependence. When a person is addicted to a drug, they might do bad or criminal acts in order to get money for more drugs, such as crimes (for example theft, robbery, fraud, or prostitution). If the person tries to stop using cocaine, they will go through cocaine withdrawal.

Another danger from using cocaine is the risk of infection when using unsafe ways of taking cocaine (like using dirty needles when injecting cocaine). A person can get infectious diseases like HIV or Hepatitis C when they use cocaine in these ways.

Cocaine as a legal medicine

Cocaine is also occasionally used as a legal medicine in Australia and some parts of Europe, if a person has a prescription from a doctor. Doctors sometimes prescribe cocaine for people who want to lose weight, because cocaine decreases the appetite.

Dentists in countries like Australia sometimes use forms of cocaine in dental operations, as an anaesthetic. Anaesthetics are medicines or drugs which stop a person from feeling pain. Doctors, surgeons, and dentists use anaesthetics when they are doing operations, so that the patient will not feel pain. Dentists put the cocaine on the patient's mouth so that the patient will not feel pain in their mouth during the operation.

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