Immunoblastic lymphoma

Immunoblastic Lymphoma is a subtype of Non-Hodgkin Lymphoma (NHL), a group of blood cancers that includes all types of lymphoma except Hodgkin's Lymphoma. Immunoblastic Lymphoma is characterized by the presence of large, abnormal lymphocytes known as immunoblasts in the lymph nodes and other tissues.

Etiology

The exact cause of Immunoblastic Lymphoma is unknown. However, it is believed to be associated with immune system dysfunction, particularly in individuals with a history of immunosuppression. Certain viral infections, such as Epstein-Barr Virus (EBV), are also thought to play a role in the development of this disease.

Clinical Presentation

Patients with Immunoblastic Lymphoma typically present with lymphadenopathy, or swollen lymph nodes, which may be accompanied by B symptoms such as fever, night sweats, and weight loss. Other symptoms may include fatigue, loss of appetite, and abdominal pain due to an enlarged spleen or liver.

Diagnosis

Diagnosis of Immunoblastic Lymphoma is typically made through a biopsy of an affected lymph node or other tissue. The biopsy sample is examined under a microscope to identify the presence of immunoblasts. Additional tests, such as immunohistochemistry, may be used to further characterize the lymphoma cells.

Treatment

Treatment for Immunoblastic Lymphoma typically involves chemotherapy, with or without radiation therapy. The specific regimen used may depend on the patient's overall health, the stage of the disease, and other factors. In some cases, a stem cell transplant may be considered.

Prognosis

The prognosis for Immunoblastic Lymphoma varies widely and depends on a number of factors, including the patient's age, overall health, and the stage of the disease at diagnosis. With appropriate treatment, many patients can achieve long-term remission.

See Also

• Lymphoma
• Non-Hodgkin Lymphoma
• Hodgkin's Lymphoma
• Epstein-Barr Virus
• Immunosuppression