Inakalant

Inakalant is a pharmaceutical drug used primarily in the treatment of cardiac arrhythmias, specifically for the conversion of atrial fibrillation to normal sinus rhythm. It is classified as a class III antiarrhythmic agent.

Mechanism of Action

Inakalant works by blocking specific ion channels in the heart, particularly the potassium channels, which are responsible for repolarization of the cardiac action potential. By inhibiting these channels, Inakalant prolongs the action potential duration and refractory period, thereby stabilizing the cardiac rhythm and preventing abnormal electrical activity that leads to arrhythmias.

Indications

Inakalant is indicated for the rapid conversion of recent-onset atrial fibrillation to sinus rhythm in adults. It is particularly useful in cases where atrial fibrillation has been present for less than 48 hours.

Administration

Inakalant is administered intravenously under medical supervision. The dosing regimen typically involves an initial bolus followed by a second dose if necessary, depending on the patient's response and clinical condition.

Side Effects

Common side effects of Inakalant include:

• Nausea
• Dizziness
• Hypotension
• Bradycardia

Serious adverse effects, although rare, may include:

• Severe hypotension
• Prolonged QT interval
• Torsades de Pointes

Contraindications

Inakalant is contraindicated in patients with:

• Severe heart failure
• Severe hypotension
• Prolonged QT interval at baseline
• Known hypersensitivity to the drug

Clinical Trials

Several clinical trials have demonstrated the efficacy and safety of Inakalant in converting atrial fibrillation to sinus rhythm. These studies have shown that Inakalant is effective in achieving rapid conversion with a favorable safety profile compared to other antiarrhythmic agents.

Regulatory Status

Inakalant is approved for use in several countries, although its availability may vary depending on local regulatory approvals.

Also see

• Atrial Fibrillation
• Antiarrhythmic Agents
• Cardiac Electrophysiology
• Potassium Channel Blockers

Cardiovascular disease A-Z

Most common cardiac diseases

• Cardiac arrhythmia‎
• Cardiogenetic disorders‎
• Cardiomegaly‎
• Cardiomyopathy‎
• Cardiopulmonary resuscitation‎
• Chronic rheumatic heart diseases‎
• Congenital heart defects‎
• Heart neoplasia‎
• Ischemic heart diseases‎
• Pericardial disorders
• Syndromes affecting the heart‎
• Valvular heart disease‎

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

A

• Accelerated idioventricular rhythm
• Acute decompensated heart failure
• Arteriosclerotic heart disease
• Athletic heart syndrome
• Atrial flutter
• Atrioventricular fistula
• Cardiovascular disease in Australia
• Autoimmune heart disease

B

• Brown atrophy of the heart

C

• Ebb Cade
• Cardiac allograft vasculopathy
• Cardiac amyloidosis
• Cardiac asthma
• Cardiac tamponade
• Cardiogenic shock
• Cardiogeriatrics
• Cardiorenal syndrome
• Cardiotoxicity
• Carditis
• Coronary artery aneurysm
• Coronary artery anomaly
• Coronary artery disease
• Spontaneous coronary artery dissection
• Coronary artery ectasia
• Coronary occlusion
• Coronary steal
• Coronary thrombosis
• Coronary vasospasm
• Cœur en sabot
• Coxsackievirus-induced cardiomyopathy

D

• Duke Treadmill Score
• Duroziez's disease

E

• Eisenmenger's syndrome
• Embryocardia
• Endocardial fibroelastosis
• Eosinophilic myocarditis

H

• Heart attack
• Heart failure
• Heart failure with preserved ejection fraction
• Heart to Heart (1949 film)
• High-output heart failure
• Hyperdynamic precordium

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

I

• Idiopathic giant-cell myocarditis
• Interventricular dyssynchrony
• Intraventricular dyssynchrony
• Isolated atrial amyloidosis

K

• Keshan disease

L

• Loeffler endocarditis

M

• Mydicar
• Myocardial bridge
• Myocardial disarray
• Myocardial rupture
• Myocardial scarring
• Myocardial stunning
• Myocarditis

N

• Nonbacterial thrombotic endocarditis

O

• OLR1
• Ostial disease

P

• Papillary fibroelastoma
• Pathophysiology of heart failure
• Postpericardiotomy syndrome
• Pulmonary vein stenosis

R

• Right axis deviation
• Roemheld syndrome

S

• Saturated fat and cardiovascular disease
• SCAR-Fc
• Shone's syndrome
• Strain pattern
• Subacute bacterial endocarditis
• Sudden cardiac death of athletes

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

T

• Traumatic cardiac arrest

V

• Ventricular aneurysm
• Vibroacoustic disease
• Viral cardiomyopathy

W

• Waon therapy