Oxoprostol
Overview[edit | edit source]
Oxoprostol is a synthetic analog of prostaglandin E1, which is used primarily for its gastroprotective and uterotonic properties. It is a compound that has been studied for its potential applications in the prevention of gastric ulcers and in obstetrics for labor induction and the management of postpartum hemorrhage.
Chemical Structure and Properties[edit | edit source]
Oxoprostol is a derivative of prostaglandin E1, characterized by modifications that enhance its stability and bioavailability. The chemical structure of Oxoprostol includes a methyl ester group, which is responsible for its increased resistance to metabolic degradation compared to natural prostaglandins.
Mechanism of Action[edit | edit source]
Oxoprostol exerts its effects by binding to specific prostaglandin receptors in the body. In the gastrointestinal tract, it promotes the secretion of mucus and bicarbonate, which protect the gastric lining from acid damage. In the uterus, Oxoprostol induces contractions by increasing intracellular calcium levels in uterine smooth muscle cells.
Clinical Uses[edit | edit source]
Gastroprotection[edit | edit source]
Oxoprostol is used to prevent gastric ulcers, particularly in patients who are taking nonsteroidal anti-inflammatory drugs (NSAIDs). Its ability to enhance mucosal defenses makes it a valuable agent in reducing the risk of NSAID-induced gastric damage.
Obstetrics[edit | edit source]
In obstetrics, Oxoprostol is used for labor induction and the management of postpartum hemorrhage. Its uterotonic properties make it effective in stimulating uterine contractions, which can facilitate childbirth and reduce bleeding after delivery.
Side Effects and Precautions[edit | edit source]
Common side effects of Oxoprostol include gastrointestinal disturbances such as diarrhea and abdominal pain. In obstetric use, careful monitoring is required to avoid excessive uterine contractions, which can lead to complications such as uterine rupture.
Research and Development[edit | edit source]
Ongoing research is exploring the potential of Oxoprostol in various therapeutic areas, including its role in the management of peptic ulcer disease and its efficacy in different obstetric protocols.
Also see[edit | edit source]
| Health science - Medicine - Gastroenterology - edit |
|---|
| Diseases of the esophagus - stomach |
| Halitosis | Nausea | Vomiting | GERD | Achalasia | Esophageal cancer | Esophageal varices | Peptic ulcer | Abdominal pain | Stomach cancer | Functional dyspepsia | Gastroparesis |
| Diseases of the liver - pancreas - gallbladder - biliary tree |
| Hepatitis | Cirrhosis | NASH | PBC | PSC | Budd-Chiari | Hepatocellular carcinoma | Acute pancreatitis | Chronic pancreatitis | Pancreatic cancer | Gallstones | Cholecystitis |
| Diseases of the small intestine |
| Peptic ulcer | Intussusception | Malabsorption (e.g. Coeliac, lactose intolerance, fructose malabsorption, Whipple's) | Lymphoma |
| Diseases of the colon |
| Diarrhea | Appendicitis | Diverticulitis | Diverticulosis | IBD (Crohn's, Ulcerative colitis) | IBS | Constipation | Colorectal cancer | Hirschsprung's | Pseudomembranous colitis |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
