Rimegepant sulfate
Rimegepant sulfate is a medication used for the acute treatment of migraine with or without aura in adults. It is a small molecule calcitonin gene-related peptide receptor (CGRP) antagonist. Rimegepant sulfate is marketed under the brand name Nurtec ODT.
Mechanism of Action[edit | edit source]
Rimegepant sulfate works by blocking the CGRP receptor, which is believed to play a crucial role in the pathophysiology of migraine. By inhibiting this receptor, rimegepant sulfate helps to alleviate migraine symptoms.
Indications[edit | edit source]
Rimegepant sulfate is indicated for the acute treatment of migraine attacks with or without aura in adults. It is not intended for the preventive treatment of migraine.
Dosage and Administration[edit | edit source]
Rimegepant sulfate is administered orally in the form of an orally disintegrating tablet (ODT). The recommended dose is 75 mg taken as needed. The tablet should be placed on the tongue and allowed to dissolve without the need for water.
Side Effects[edit | edit source]
Common side effects of rimegepant sulfate include:
Contraindications[edit | edit source]
Rimegepant sulfate is contraindicated in patients with a history of hypersensitivity to rimegepant or any of its components.
Pharmacokinetics[edit | edit source]
Rimegepant sulfate is rapidly absorbed after oral administration, with peak plasma concentrations occurring approximately 1.5 hours post-dose. It is metabolized primarily by the liver and excreted in the urine and feces.
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