Rimegepant
What is Rimegepant?[edit]
Rimegepant is a Calcitonin Gene-related Peptide (CGRP) receptor oral antagonist.
What are the uses of this medicine?[edit]
This medicine is used to treat acute migraines.
How does this medicine work?[edit]
This medicine works by blocking CGRP receptors which are thought to be involved in migraine pathophysiology.
Who Should Not Use this medicine?[edit]
Rimegepant cannot be co-administered with certain medication, so consult doctor before taking.
Is this medicine FDA approved?[edit]
Yes, this medicine received FDA approval on February 27, 2020.
How should this medicine be used?[edit]
Rimegepant is taken orally, it should be dissolved on or under the tongue without any additional liquid. It takes an hour to be effective and provides relief for up to 48 hours.
What are the dosage forms and brand names of this medicine?[edit]
Rimegepant is sold under the name Nurtec ODT which was developed by Biohaven Pharmaceuticals.
Dosage for treating migraines:[edit]
75 mg PO as needed
Not to exceed 75 mg per 24-hr period
Safety of >18 doses/30 days has not been established
Dosage for preventing migraines[edit]
Indicated for preventive treatment of episodic migraine
75 mg PO every other day
What side effects can this medication cause?[edit]
Adverse side effects include nausea and hypersensitivity, including dyspnea and severe rash.
What special precautions should I follow?[edit]
Use dry hands when opening the package of Nurtec ODT, and take immediately after opening.
Ask doctor before using this medication to ensure it does not negatively interact with your other medication.
What to do in case of emergency/overdose?[edit]
- In case of overdose, call the poison control helpline of your country. In the United States, call 1-800-222-1222.
- Overdose related information is also available online at poisonhelp.org/help.
- In the event that the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services. In the United States, call 911.
Can this medicine be used in pregnancy?[edit]
Data are not available regarding the developmental risk associated with use in pregnant women.
Can this medicine be used in children?[edit]
Use in children has not yet been established.
What should I know about storage and disposal of this medication?[edit]
Store at 20-25ºC (68-77ºF); excursions permitted to 15-30ºC (59-86ºF).
Do not store Nurtec ODT outside the blister package for future use.
External links[edit]
- Rimegepant(link). U.S. National Library of Medicine.
- Clinical trial number NCT03461757 for "Trial in Adult Subjects With Acute Migraines" at ClinicalTrials.gov
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