Glucose tolerance
Glucokinase regulator (GKRP) is a protein that in humans is encoded by the GCKR gene. It is an important component of the glucose homeostasis mechanism in the liver.
Function[edit | edit source]
Glucokinase (GK) is a key enzyme in the regulation of carbohydrate metabolism. It functions as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. The glucokinase regulator protein binds to GK in the nucleus and inhibits its activity. This binding is reversible, and is mediated by fructose metabolites. When fructose-1-phosphate is high, the glucokinase regulator protein releases GK to the cytoplasm, where it can stimulate glycolysis.
Clinical significance[edit | edit source]
Mutations in the GCKR gene have been associated with type 2 diabetes, hypertriglyceridemia, and polycystic ovary syndrome. Studies have also suggested a link between the GCKR gene and fatty liver disease.
See also[edit | edit source]
- Glucokinase
- Glycolysis
- Type 2 diabetes
- Hypertriglyceridemia
- Polycystic ovary syndrome
- Fatty liver disease
References[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
 | This gene article is a stub. You can help WikiMD by expanding it. |
 | This endocrinology article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
