Irenka
Irenka
| Irenka | |
|---|---|
| |
| INN | |
| Drug class | |
| Routes of administration | Oral |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | Hepatic |
| Elimination half-life | 12 hours |
| Excretion | Urine |
| Legal status | |
| CAS Number | 116539-59-4 |
| PubChem | 60835 |
| DrugBank | DB00476 |
| ChemSpider | 54847 |
| KEGG | D07880 |
Irenka is a brand name for the drug duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI) used primarily in the treatment of major depressive disorder and generalized anxiety disorder. It is also prescribed for the management of neuropathic pain associated with diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain.
Pharmacology[edit | edit source]
Mechanism of Action[edit | edit source]
Irenka works by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, which increases the levels of these neurotransmitters in the synaptic cleft. This action is believed to contribute to its antidepressant, anxiolytic, and analgesic effects.
Pharmacokinetics[edit | edit source]
Irenka is well absorbed after oral administration, with peak plasma concentrations occurring approximately 6 hours post-dose. It is extensively metabolized in the liver by the cytochrome P450 enzymes, primarily CYP1A2 and CYP2D6. The elimination half-life of duloxetine is approximately 12 hours, and it is excreted mainly in the urine.
Indications[edit | edit source]
Irenka is indicated for the treatment of:
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
- Diabetic peripheral neuropathic pain
- Fibromyalgia
- Chronic musculoskeletal pain
Contraindications[edit | edit source]
Irenka is contraindicated in patients with:
- Hypersensitivity to duloxetine or any of the excipients in the formulation
- Concurrent use of monoamine oxidase inhibitors (MAOIs)
- Uncontrolled narrow-angle glaucoma
Adverse Effects[edit | edit source]
Common adverse effects of Irenka include:
Serious adverse effects may include:
Interactions[edit | edit source]
Irenka may interact with:
- Monoamine oxidase inhibitors (MAOIs)
- Selective serotonin reuptake inhibitors (SSRIs)
- Tricyclic antidepressants (TCAs)
- Warfarin
Dosage and Administration[edit | edit source]
Irenka is administered orally, with or without food. The dosage varies depending on the condition being treated and the patient's response to therapy. It is important to follow the prescribing physician's instructions and not to discontinue the medication abruptly.
See Also[edit | edit source]
- Duloxetine
- Serotonin-norepinephrine reuptake inhibitor
- Major depressive disorder
- Generalized anxiety disorder
External Links[edit | edit source]
Drug groups | Encyclopedia | Dictionary | Cancer drugs | OTC | Alternative meds | Drugs | Medications A-Z | FDA approved products | Portal:Pharmacology
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