Limbic encephalitis with LGI1 antibodies

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Alternate names[edit | edit source]

Limbic encephalitis with leucine-rich glioma-inactivated 1 antibodies

Definition[edit | edit source]

Limbic encephalitis with LGI1 antibodies is a relatively new disease characterized by progressive memory loss, confusion, sleep disturbances, and problems with behaviors and spatial orientation.

Cause[edit | edit source]

The disease occurs when antibodies mistakenly attack LGI1 (leucine-rich glioma inactivated 1), a protein found in the brain that binds together two epilepsy-related proteins called ADAM22 and ADAM23.

Signs and symptoms[edit | edit source]

  • This condition ischaracterized by progressive memory loss, confusion, sleep disturbances, and problems with behaviors and spatial orientation.
  • Seizures are common and frequently precede other symptoms.
  • About half of people with this diagnosis exhibit a specific type of seizure called faciobrachial dystonic seizures, which resemble brief jerks of the face arm.
  • Hyponatremia (low levels of sodium in the blood) may also be present.

Diagnosis[edit | edit source]

  • Some people with limbic encephalitis with LGI1 antibodies (5 to 10%) also have a cancer diagnosis (most commonly thymoma and lung cancer), but most do not.
  • The disease is diagnosed through testing of blood or spinal fluid for LGI1 antibodies.

Treatment[edit | edit source]

Prognosis[edit | edit source]

  • Long-term outcome is mostly favorable, although some people are left with some degree of residual impairment.
  • Relapse occurs in up to one third of patients.



NIH genetic and rare disease info[edit source]

Limbic encephalitis with LGI1 antibodies is a rare disease.


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